Number of infants with a caries increment · Infants/young children (primary teeth; baseline about 1 to 3 years)
Xylitol sucking tablets (1 g/day) showed no clear difference in number of infants with a caries increment compared with no treatment; GRADE not reported.
1 finding from 1 review
Caries increment (dmfs, primary and permanent teeth combined) · Children (mixed dentition; baseline about 8 years)
1 finding from 1 review
One study (252 children) compared xylitol (7.5 g/day) candy with control (sorbitol) candy over 36 months. The data could not be used in analysis because the authors combined primary/deciduous and permanent teeth and…
1 study · 252 participants
GRADE not reported
Caries in primary teeth (mean number of decayed primary teeth) · Infants (primary teeth; baseline about 9 to 15 months)
1 finding from 1 review
Caries increment, surface index D(M)FS · Children (permanent teeth; baseline 8 to 10 years)
1 finding from 1 review
Caries increment, surface index D(M)FS · Infants/young children (primary teeth; baseline about 1 to 3 years)
1 finding from 1 review
Number of children with a caries increment · Children (permanent teeth; baseline 8 to 10 years)
Xylitol lozenges (4.7 g/day) showed no clear difference in number of children with a caries increment compared with no treatment; GRADE not reported.
1 finding from 1 review
Caries increment, surface index D(M)FS · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment in deciduous (primary) teeth/surfaces (dmf index) · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment in permanent teeth · Children and adolescents aged 16 years or less
2 findings from 1 review
Caries increment in permanent teeth · Children and adolescents aged 16 years or less
3 findings from 1 review
Caries increment on permanent tooth surfaces (DMFS, approximal surfaces) · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment in deciduous (primary) teeth/surfaces (dmf index) · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries in deciduous teeth (change in dmft) · Children and adolescents aged 16 years or less
1 finding from 1 review
Adverse effects · Children (permanent teeth; baseline 8 to 10 years)
1 finding from 1 review
Adverse effects (loose stools, diarrhoea) · Infants (primary teeth; baseline about 9 to 15 months)
1 finding from 1 review
Adverse effects were not reported in a usable format, but the reported rates of loose stools and diarrhoea were very similar between groups. There were no serious adverse effects during the study. Milgrom 2009.
1 study · 94 participants
GRADE not reported
Adverse effects · Children (mixed dentition; baseline about 8 years)
1 finding from 1 review
Fluorosis (adverse effect; % of children with fluorotic teeth) · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Plaque and gingivitis scores · Children and adolescents aged 16 years or less
1 finding from 1 review
Fluorosis (adverse effect; % of children with fluorotic teeth, questionable to severe) · Children and adolescents aged 16 years or less
1 finding from 1 review
% of children with fluorotic teeth (questionable to severe), follow-up 55 months. Assumed risk 32/212 = 15%; corresponding risk 40/202 = 20% (APF once a day) and 43/197 = 22% (APF twice a day). Relative effect: Not…
1 study · 611 participants
Very low