What do systematic reviews say?

0.1% triamcinolone acetonide in orabase vs ciclosporin

0.1% triamcinolone acetonide in orabase showed no clear difference in physician Global Assessment (Thongprasom score) compared with ciclosporin solution; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD 0.61 [-0.79, 2.01]
  1 study · 11 participants
  GRADE not reported

Topical clobetasol propionate 0.025% vs clobetasol cream 0.05% cream

Topical clobetasol propionate 0.025% showed no clear difference in physician Global Assessment (Thongprasom score) compared with topical clobetasol propionate 0.05%; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD 0.47 [-0.26, 1.20]
  1 study · 35 participants
  GRADE not reported

Topical ciclosporin 1.5% gel vs Topical clobetasol propionate 0.025% gel

Topical ciclosporin 1.5% gel showed no clear difference in physician Global Assessment (Thongprasom score) compared with topical clobetasol propionate 0.025% gel; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  RR 3.16 [1.00, 9.93]
  1 study · 40 participants
  GRADE not reported

1% pimecrolimus cream vs Placebo (vehicle cream)

1% pimecrolimus cream showed no clear difference in physician Global Assessment (surface of erosive lesions) compared with placebo (vehicle cream); GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD -0.50 [-1.39, 0.39]
  1 study · 12 participants
  GRADE not reported

1% pimecrolimus cream vs Placebo (vehicle cream)

1% pimecrolimus cream led to higher physician Global Assessment (strong improvement) compared with placebo (vehicle cream); GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  RR 7.00 [1.04, 46.95]
  1 study · 20 participants
  GRADE not reported

1% pimecrolimus cream vs Placebo (vehicle cream)

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  One study (Passeron 2007) assessed participant global self-assessment on a 5-point scale: 5/6 participants in the 1% pimecrolimus group rated their improvement as moderate or important versus 1/6 in the placebo group…
  1 study · 12 participants
  GRADE not reported

Fluocinonide in adhesive base vs placebo

Fluocinonide in adhesive base showed no clear difference in physician Global Assessment (clinical signs, complete response) compared with placebo; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  RR 4.67 [0.24, 88.96]
  1 study · 27 participants
  GRADE not reported

Radix tripterygium hypoglaucum tablet (THT) vs Tripterygium glucosides tablet (TGT)

Radix tripterygium hypoglaucum tablet (THT) showed no clear difference in physician Global Assessment (cure of erosive lesions, remarkably… compared with tripterygium glucosides tablet (TGT); GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes

  Grade II (erosive lesions only)
  RR 0.73 [0.42, 1.28]
  1 study · 94 participants
  GRADE not reported
• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes

  Grade I (erosive and ulcerative lesions)
  RR 0.55 [0.25, 1.20]
  1 study · 94 participants
  GRADE not reported

1% pimecrolimus cream vs Placebo (vehicle cream)

1% pimecrolimus cream showed no clear difference in physician Global Assessment (weighted sums of ulceration, erythema,… compared with placebo (vehicle cream); GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD -56.57 [-134.02, 20.88]
  1 study · 20 participants
  GRADE not reported

Aloe vera gel vs placebo

Aloe vera gel showed no clear difference in physician Global Assessment (Thongprasom score) compared with placebo; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  RR 2.64 [0.11, 61.54]
  1 study · 45 participants
  GRADE not reported

Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste

Betamethasone oral mini-pulse therapy led to higher physician Global Assessment (clinical severity, 0-12 score) compared with topical triamcinolone acetonide 0.1% paste; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes

  24 weeks
  MD 1.78 [0.17, 3.39]
  1 study · 22 participants
  GRADE not reported

Clobetasol-17-propionate 0.025% lipid-loaded microspheres vs Clobetasol propionate 0.025% ointment

Clobetasol-17-propionate 0.025% lipid-loaded microspheres showed no clear difference in physician Global Assessment (Thongprasom score) compared with conventional 0.025% clobetasol lipophilic ointment in hydrophilic…; GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD 0.00 [-0.61, 0.61]
  1 study · 45 participants
  GRADE not reported

Ciclosporin rinse vs Placebo (vehicle cream)

Ciclosporin rinse led to lower physician Global Assessment (severity of disease) compared with placebo (vehicle); GRADE not reported.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  MD -1.40 [-1.86, -0.94]
  1 study · 8 participants
  GRADE not reported