Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

30 questions · 30 findings · 5 reviews

No studies found 11 · 36.7%GRADE not reported 2 · 6.7%Very low 12 · 40%Low 2 · 6.7%Moderate 3 · 10%High 0 · 0%

Antithrombin vs no thromboprophylaxis

Major bleeding · ambulatory paediatric cancer patients newly diagnosed with acute lymphoblastic leukaemia who received chemotherapy

It is very uncertain whether antithrombin changes major bleeding compared with no thromboprophylaxis (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Antithrombin concentrates vs no antithrombin concentrates

Death Analysis 1.1 · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy

It is very uncertain whether summary of Findings Table ‐ Antithrombin concentrates changes all‐cause mortality ‐ Intention‐to‐treat analysis compared with no antithrombin concentrates (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Antithrombin concentrates vs no antithrombin concentrates

Venous thromboembolism‐related mortality ‐ Intention‐to‐treat analysis · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy

It is very uncertain whether summary of Findings Table ‐ Antithrombin concentrates changes venous thromboembolism‐related mortality ‐ Intention‐to‐treat analysis compared with no antithrombin concentrates (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Antithrombin concentrates vs no antithrombin concentrates

Clinically relevant non‐major bleeding ‐ not reported · adults with acute lymphoblastic leukaemia treated with asparaginase‐based chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: Antithrombin III plus heparin vs heparin

Incidence of hepatic veno‐occlusive disease ( · Patients undergoing stem cell transplant with malignant and non‐malignant diseases

It is very uncertain whether summary of findings: Antithrombin III plus heparin changes incidence of hepatic veno‐occlusive disease ( compared with heparin alone (very low certainty).

1 finding from 1 review