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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 5 findings · 1 reviews · Acute Respiratory Infections

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 20%High 4 · 80%

Antihistamines vs placebo

Change in severity of overall symptoms: short‐term (1 to 2 days) Subjective severity score · patients with common cold

Antihistamines probably leads to lower change in severity of overall symptoms: short‐term Subjective… compared with placebo (moderate certainty).

1 finding from 1 review

Antihistamines vs placebo

Change in severity of overall symptoms: intermediate‐term (3 to 4 days) Subjective severity score · patients with common cold

Antihistamines showed no clear difference in change in severity of overall symptoms: intermediate‐term (3 to 4… compared with placebo (high certainty).

1 finding from 1 review

Antihistamines vs placebo

Change in severity of overall symptoms: long‐term (6 to 10 days) Subjective severity score · patients with common cold

Antihistamines showed no clear difference in change in severity of overall symptoms: long‐term (6 to 10 days)… compared with placebo (high certainty).

1 finding from 1 review

Sedating antihistamines vs placebo

Change in severity of overall symptoms: short‐term (1 to 2 days) Subjective severity score · patients with common cold

Sedating antihistamines leads to lower change in severity of overall symptoms: short‐term (1 to 2 days)… compared with placebo (high certainty).

1 finding from 1 review

Sedating antihistamines vs placebo

Change in severity of overall symptoms: long‐term (6 to 10 days) Subjective severity score · patients with common cold

Sedating antihistamines showed no clear difference in change in severity of overall symptoms: long‐term (6 to 10 days)… compared with placebo (high certainty).

1 finding from 1 review