Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews · Temporomandibular disorders and sleep · All outcomes

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No studies found 1 · 20%GRADE not reported 4 · 80%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Oral gabapentin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
12 weeks
Four of the participants withdrew from the study by Kimos et al 2007 due to adverse effects, but neither the type of adverse effect nor the trial group was specified.
1 study · 44 participants
GRADE not reported

Oral gabapentin vs placebo

Participants' assessment of global function (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral gabapentin (anticonvulsant) showed no clear difference in participants' assessment of global function (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
12 weeks
MD -1.50 [-3.10, 0.10]
1 study · 44 participants
GRADE not reported

Number of tender sites on muscles of mastication (palpation index) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral gabapentin (anticonvulsant) led to lower number of tender sites on muscles of mastication (palpation index) compared with placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
12 weeks
MD -4.56 [-6.99, -2.13]
1 study · 44 participants
GRADE not reported

Oral gabapentin vs placebo

Spontaneous pain in the TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral gabapentin (anticonvulsant) led to lower spontaneous pain in the TMJ (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
12 weeks
MD -3.20 [-4.71, -1.69]
1 study · 44 participants
GRADE not reported

Occlusal splint vs Pharmacological interventions (benzodiazepines, anticonvulsants, beta blockers, dopamine agents, antidepressants, botulinum toxin A and B, analgesics)

Outcome not reported · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

The review found no eligible studies for this question.

1 finding from 1 review

Occlusal splints for treating sleep bruxism (tooth grinding) 2007 · Cochrane All outcomes
Pharmacological interventions remained a planned comparator, but no included trial compared occlusal splint with any drug; no eligible study.
0 studies
No studies found