What do systematic reviews say?

Anticholinergic and short‐acting beta2‐agonists vs B2‐agonists alone

Anticholinergic and short‐acting beta2‐agonists leads to lower primary outcome: hospital admissions hospital admissions compared with beta2‐agonists alone (all protocols) (high certainty).

• Combined inhaled anticholinergics and short‐acting beta₂‐agonists for initial treatment of acute asthma in children 2013 · Cochrane Headline outcomes only
  RR 0.73 [0.63, 0.85]
  19 studies · 2497 participants
  High

Combination of anticholinergics + beta2‐agonists vs B2‐agonists alone

• Inhaled anticholinergics and short‐acting beta₂‐agonists versus short‐acting beta2‐agonists alone for children with… 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 269 participants
  Moderate

Combination of anticholinergics + beta2‐agonists vs B2‐agonists alone

• Inhaled anticholinergics and short‐acting beta₂‐agonists versus short‐acting beta2‐agonists alone for children with… 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 327 participants
  Moderate

Combination of anticholinergics + beta2‐agonists vs B2‐agonists alone

Combination of anticholinergics + beta2‐agonists showed no clear difference in asthma clinical scores compared with beta2‐agonists alone (moderate certainty).

• Inhaled anticholinergics and short‐acting beta₂‐agonists versus short‐acting beta2‐agonists alone for children with… 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 117 participants
  Moderate

Combination of anticholinergics + beta2‐agonists vs B2‐agonists alone

• Inhaled anticholinergics and short‐acting beta₂‐agonists versus short‐acting beta2‐agonists alone for children with… 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 210 participants
  Moderate

Combination of anticholinergics + beta2‐agonists vs B2‐agonists alone

Combination of anticholinergics + beta2‐agonists showed no clear difference in overall withdrawals compared with beta2‐agonists alone (moderate certainty).

• Inhaled anticholinergics and short‐acting beta₂‐agonists versus short‐acting beta2‐agonists alone for children with… 2014 · Cochrane Headline outcomes only
  OR 0.59 [0.27, 1.3]
  2 studies · 294 participants
  Moderate

Combination of anticholinergics + beta2‐agonists vs B2‐agonists alone

• Inhaled anticholinergics and short‐acting beta₂‐agonists versus short‐acting beta2‐agonists alone for children with… 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 290 participants
  Moderate