Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

14 questions · 15 findings · 2 reviews · Kidney and Transplant · Headline outcomes only

No studies found 2 · 13.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 8 · 53.3%Moderate 5 · 33.3%High 0 · 0%

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Number of participants with symptomatic UTI · primary VUR

Antibiotic prophylaxis showed no clear difference in symptomatic UTI by 1 to 2 years: antibiotics versus no prophylaxis compared with surveillance or no treatment (low certainty).

2 findings from 1 review

Probiotics vs antibiotic prophylaxis

Renal parenchymal defects on DMSA scan ‐ Patient data at 1 year · primary VUR

Probiotics showed no clear difference in renal parenchymal defects on DMSA scan ‐ Patient data at 1 year compared with antibiotic prophylaxis (low certainty).

1 finding from 1 review