Findings

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8 questions · 9 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 44.4%Moderate 2 · 22.2%High 3 · 33.3%

Analgesic‐decongestant vs placebo

Adverse effects: all · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant leads to higher adverse effects: all compared with placebo (high certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.62 [1.18, 2.23]
6 studies · 1797 participants
High

Analgesic‐decongestant vs placebo

Adverse effects: drowsiness, hypersomnia, lethargy, excessive sleepiness, and other central nervous system adverse effects · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant showed no clear difference in adverse effects: drowsiness, hypersomnia, lethargy, excessive… compared with placebo (moderate certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.34 [0.76, 2.37]
5 studies · 1644 participants
Moderate

Analgesic‐decongestant vs placebo

Adverse effects: dry mouth · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant showed no clear difference in adverse effects: dry mouth compared with placebo (low certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.43 [0.53, 3.83]
3 studies · 764 participants
Low

Analgesic‐decongestant vs placebo

Gastrointestinal adverse events · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant showed no clear difference in adverse effects: gastrointestinal compared with placebo (high certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
RR 1.71 [0.97, 3.01]
5 studies · 1644 participants
High

Analgesic‐decongestant vs placebo

Adverse effects: dizziness, lightheadedness · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant leads to higher adverse effects: dizziness, lightheadedness compared with placebo (high certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 2.86 [1.02, 8.01]
4 studies · 1287 participants
High

Analgesic‐decongestant vs placebo

Global evaluation · otherwise healthy adults and children with common cold symptoms

Analgesic‐decongestant probably leads to lower global evaluation compared with placebo (moderate certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 0.28 [0.15, 0.52]
1 study · 181 participants
Moderate

Antihistamine‐analgesic‐decongestant vs placebo

Global evaluation · otherwise healthy adults and children with common cold symptoms

Antihistamine‐analgesic‐decongestant showed no clear difference in global evaluation: after 3 days of treatment (included children 2 to… compared with placebo (low certainty).

2 findings from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 0.34 [0.09, 1.31]
1 study · 109 participants
Low
Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 0.47 [0.33, 0.67]
2 studies · 548 participants
Low

Antihistamine‐analgesic‐decongestant vs placebo

Global evaluation: after 5 days of treatment (included children 2 to 12 years old only) · otherwise healthy adults and children with common cold symptoms

Antihistamine‐analgesic‐decongestant showed no clear difference in global evaluation: after 5 days of treatment (included children 2 to… compared with placebo (low certainty).

1 finding from 1 review

Oral antihistamine‐decongestant‐analgesic combinations for the common cold 2022 · Cochrane Headline outcomes only
OR 1.17 [0.49, 2.77]
1 study · 83 participants
Low