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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 5 findings · 1 reviews · Common Mental Disorders · Headline outcomes only

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No studies found 2 · 40%GRADE not reported 0 · 0%Very low 1 · 20%Low 0 · 0%Moderate 2 · 40%High 0 · 0%

Amitriptyline vs placebo

Response rates Number of participants showing a reduction of at least 50% on the Hamilton Depression Rating Scale for Depression, the Montgomery‐Asberg Depression Rating Scale or any other depression scale · adults with Major Depressive Disorder

Amitriptyline probably leads to higher response to treatment At least 50% reduction of a depression scale… compared with placebo (moderate certainty).

1 finding from 1 review

Amitriptyline vs placebo

Acceptability of treatment Drop‐out for any reason · adults with Major Depressive Disorder

It is very uncertain whether amitriptyline changes acceptability of treatment Drop‐out for any reason compared with placebo (very low certainty).

1 finding from 1 review

Amitriptyline vs placebo

Adverse effects (drop‐outs due to adverse effects4) · adults with Major Depressive Disorder

Amitriptyline probably leads to higher overall tolerability Drop‐out due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review