Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Hypertension

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 4 · 57.1%High 0 · 0%

First‐line thiazides vs alpha‐blocker

Total mortality Duration: 3.2 years · patients with hypertension

First‐line thiazides showed no clear difference in total mortality Duration: 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
RR 0.98 [0.88, 1.09]
1 study · 24316 participants
Moderate

First‐line thiazides vs alpha‐blocker

Total serious adverse events · patients with hypertension

The review found no eligible studies for this question.

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

First‐line thiazides vs alpha‐blocker

Cardiovascular events · patients with hypertension

First‐line thiazides probably leads to lower total cardiovascular events Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
RR 0.74 [0.69, 0.8]
2 studies · 24396 participants
Moderate

First‐line thiazides vs alpha‐blocker

Stroke · patients with hypertension

First‐line thiazides showed no clear difference in total stroke Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
RR 0.86 [0.73, 1.01]
2 studies · 24396 participants
Moderate

First‐line thiazides vs alpha‐blocker

Total CHD Duration: 1 to 5.8 years · patients with hypertension

First‐line thiazides showed no clear difference in total CHD Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (low certainty).

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
RR 0.98 [0.86, 1.11]
2 studies · 24396 participants
Low

First‐line thiazides vs alpha‐blocker

Congestive heart failure · patients with hypertension

First‐line thiazides probably leads to lower total congestive heart failure Duration: 3.2 years compared with first‐line alpha‐blockers (moderate certainty).

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
RR 0.51 [0.45, 0.58]
1 study · 24316 participants
Moderate

First‐line thiazides vs alpha‐blocker

Withdrawals due to adverse events · patients with hypertension

First‐line thiazides may leads to lower withdrawals due to adverse effects Duration: 1 to 3.2 years compared with first‐line alpha‐blockers (low certainty).

1 finding from 1 review

First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only
RR 0.7 [0.54, 0.89]
3 studies · 24772 participants
Low