Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

41 questions · 41 findings · 5 reviews · Headline outcomes only

No studies found 6 · 14.6%GRADE not reported 0 · 0%Very low 11 · 26.8%Low 13 · 31.7%Moderate 11 · 26.8%High 0 · 0%

Acyclovir vs placebo, vitamins, or no treatment

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Acyclovir probably leads to lower proportion of participants with resolution of itch within 2 weeks,… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea

Acyclovir probably leads to higher the proportion of participants with good or excellent rash… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

Acyclovir showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Acyclovir vs erythromycin

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Acyclovir vs erythromycin

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Acyclovir showed no clear difference in the proportion of participants with resolution of itch within 2… compared with erythromycin (low certainty).

1 finding from 1 review

Acyclovir vs erythromycin

Reduction in itch score within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Acyclovir vs erythromycin

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea
1 finding from 1 review