Time to alignment · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Active self-ligating brackets showed no clear difference in time to alignment (days) compared with passive self-ligating brackets; GRADE not reported.
1 finding from 1 review
Amount of crowding (upper anterior crowding) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
1 finding from 1 review
Ion release (fluoride, calcium, phosphate) · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, among the 5 BAG ion-release studies only Ga-doped BAG (GaMBN, Song [31]) reported a significant increase (phosphate, up to 14 days); a general significant fluoride/calcium/phosphate increase across all 5 is not supported (ungraded).
1 finding from 1 review
Enamel remineralization / anti-demineralization extent · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, most bioactive glass-containing orthodontic adhesives (9 of 13 studies) showed significant enamel remineralization/anti-demineralization versus control, but the evidence is weak (predominantly high risk of bias, methodological heterogeneity, no meta-analysis; ungraded).
1 finding from 1 review
Out of 13 studies that evaluated bioactive glass particles/nanoparticles, 9 reported definitive statistically significant remineralization potential compared to control orthodontic adhesives [17, 21-24, 26-28, 31]; one…
13 studies
GRADE not reported
Duration of orthodontic treatment, number of visits during active treatment (scheduled and unscheduled) and duration of visits · Individuals of any age receiving orthodontic treatment with fixed appliances (braces) (people requiring orthodontic tooth movement);…
The review found no eligible studies for this question.
1 finding from 1 review
Plaque · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
In randomized trials, clear aligners probably reduce plaque accumulation versus fixed appliances, though the subgroup estimate is imprecise and its CI crosses no effect (SMD -1.79, 95% CI -3.63 to 0.04; moderate certainty).
6 findings from 1 review
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White spot lesion incidence · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
Most studies reported a lower incidence of white spot lesions with clear aligners than fixed appliances, but heterogeneous assessment methods precluded meta-analysis (ungraded).
1 finding from 1 review
Severity of white spot lesions (surface area and depth) · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
White spot lesion severity was assessed narratively in a small number of studies and not meta-analyzed; evidence is limited (ungraded).
1 finding from 1 review
Salivary caries-associated bacteria (S. mutans and Lactobacilli, subjects with >10^5 CFU/mL) · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
Both included studies reported higher salivary caries-associated bacteria (S. mutans and Lactobacilli) with fixed appliances than clear aligners; not meta-analyzed (ungraded).
1 finding from 1 review
Size of the lower jaw (arch length, change) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Schwarz appliance showed no clear difference in size of the lower jaw (mandibular arch length, change) at 9 months compared with no active treatment (control); GRADE not reported.
1 finding from 1 review
Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
1 finding from 1 review
Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
It is very uncertain whether lower lip bumper changes amount of crowding (change in mandibular incisor crowding) at 6 months compared with no active treatment (control) (very low certainty).
1 finding from 1 review
Lower incisors to mandible (position, mm) at 9 months · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Lower lip bumper led to higher lower incisors to mandible at 6 months compared with no active treatment (control); GRADE not reported.
1 finding from 1 review
Size of the lower jaw (arch length) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Lower lip bumper led to higher size of the lower jaw (mandibular arch length) at 6 months compared with no active treatment (control); GRADE not reported.
1 finding from 1 review
Amount of crowding (change in mandibular crowding) at 8 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
It is very uncertain whether schwarz appliance changes amount of crowding (lower arch crowding, change) at 9 months compared with no active treatment (control) (very low certainty).
1 finding from 1 review
Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
It is very uncertain whether extraction of third molars (wisdom teeth) changes amount of crowding (Little's Irregularity Index, change) at 5 years compared with no active treatment (control) (very low certainty).
1 finding from 1 review
Size of the lower jaw (arch length) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Lower lingual arch led to higher size of the lower jaw (mandibular arch length) at 1 year compared with no active treatment (control); GRADE not reported.
1 finding from 1 review
Lower incisor inclination (lingual tipping and retrusion) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Extraction of lower deciduous canines showed no clear difference in lower incisors to mandible (inclination, degrees) at 1 year compared with no active treatment (control); GRADE not reported.
1 finding from 1 review
Position of the incisors (upper incisor inclination) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
Schwarz appliance showed no clear difference in upper incisors to maxilla (inclination, degrees) at 9 months compared with no active treatment (control); GRADE not reported.
1 finding from 1 review
Amount of crowding (number of children with crowding, mandible) after 1 year · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
It is very uncertain whether eruption guidance appliance changes amount of crowding (number of children with crowding, mandible)… compared with no active treatment (control) (very low certainty).
1 finding from 1 review