Findings

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Evidence found and GRADE certainty

32 questions · 32 findings · 4 reviews · Infectious Diseases

No studies found 1 · 3.1%GRADE not reported 6 · 18.8%Very low 6 · 18.8%Low 14 · 43.8%Moderate 2 · 6.3%High 3 · 9.4%

Pyronaridine‐artesunate (PY‐AS) vs artesunate‐amodiaquine (AS‐AQ)

First treatment, abnormal ALT increase (42 days) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in first treatment, abnormal ALT increase (42 days) compared with artesunate‐amodiaquine (AS‐AQ) (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artesunate‐amodiaquine (AS‐AQ)

First treatment, abnormal AST increase (42 days) · adults and children with uncomplicated P falciparum malaria

It is very uncertain whether pyronaridine‐artesunate (PY‐AS) changes first treatment, abnormal AST increase (42 days) compared with artesunate‐amodiaquine (AS‐AQ) (very low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artesunate‐amodiaquine (AS‐AQ)

First treatment, abnormal bilirubin increase (42 days) · adults and children with uncomplicated P falciparum malaria

It is very uncertain whether pyronaridine‐artesunate (PY‐AS) changes first treatment, abnormal bilirubin increase (42 days) compared with artesunate‐amodiaquine (AS‐AQ) (very low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs mefloquine plus artesunate (MQ + AS)

First treatment, abnormal ALT increase (42 days) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in first treatment, abnormal ALT increase (42 days) compared with mefloquine plus artesunate (MQ + AS) (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs mefloquine plus artesunate (MQ + AS)

First treatment, abnormal AST increase (42 days) · adults and children with uncomplicated P falciparum malaria

It is very uncertain whether pyronaridine‐artesunate (PY‐AS) changes first treatment, abnormal AST increase (42 days) compared with mefloquine plus artesunate (MQ + AS) (very low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs mefloquine plus artesunate (MQ + AS)

First treatment, abnormal bilirubin increase (42 days) · adults and children with uncomplicated P falciparum malaria

It is very uncertain whether pyronaridine‐artesunate (PY‐AS) changes first treatment, abnormal bilirubin increase (42 days) compared with mefloquine plus artesunate (MQ + AS) (very low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs other antimalarials

First treatment, abnormal AST increase (42 days) · adults and children with uncomplicated malaria

Pyronaridine‐artesunate (PY‐AS) probably leads to higher first treatment, abnormal AST increase compared with other antimalarials (moderate certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs other antimalarials

First treatment, abnormal bilirubin increase (42 days) · adults and children with uncomplicated malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in first treatment, abnormal bilirubin increase compared with other antimalarials (moderate certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs other antimalarials

Subsequent treatment(s), abnormal ALT increase · adults and children with uncomplicated malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in subsequent treatment(s), abnormal ALT increase compared with other antimalarials (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs other antimalarials

Subsequent treatment(s), abnormal AST increase · adults and children with uncomplicated malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in subsequent treatment(s), abnormal AST increase compared with other antimalarials (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs other antimalarials

Subsequent treatment(s), abnormal bilirubin increase · adults and children with uncomplicated malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in subsequent treatment(s), abnormal bilirubin increase compared with other antimalarials (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

First treatment, abnormal ALT increase (42 days) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) may leads to higher first treatment, abnormal ALT increase (42 days) compared with artemether‐lumefantrine (AL) (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

First treatment, abnormal AST increase (42 days) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) may leads to higher first treatment, abnormal AST increase (42 days) compared with artemether‐lumefantrine (AL) (low certainty).

1 finding from 1 review

Pyronaridine‐artesunate (PY‐AS) vs artemether‐lumefantrine (AL)

First treatment, abnormal bilirubin increase (42 days) · adults and children with uncomplicated P falciparum malaria

Pyronaridine‐artesunate (PY‐AS) showed no clear difference in first treatment, abnormal bilirubin increase (42 days) compared with artemether‐lumefantrine (AL) (low certainty).

1 finding from 1 review

Mefloquine vs doxycycline

Abnormal thoughts or perceptions · Non‐immune adults and children travelling to malaria‐endemic settings

Mefloquine showed no clear difference in abnormal thoughts or perceptions compared with doxycycline; GRADE not reported.

1 finding from 1 review