Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 17 findings · 4 reviews · Cystic Fibrosis and Genetic Disorders · Headline outcomes only

No studies found 5 · 29.4%GRADE not reported 0 · 0%Very low 8 · 47.1%Low 4 · 23.5%Moderate 0 · 0%High 0 · 0%

Intervention not reported

Abnormally large livers reduced to within normal limits, as measured by ultrasound · adults and children with cystic fibrosis‐related liver disease

The review found no eligible studies for this question.

1 finding from 1 review

Deferasirox vs placebo

AE: abnormal serum creatinine (post‐baseline) · people with non‐transfusion‐dependent thalassemia

It is very uncertain whether deferasirox changes AE: abnormal serum creatinine (post‐baseline) compared with placebo (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs usual care

SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and abnormal TCD velocities

It is very uncertain whether long‐term RBC transfusion changes SCD‐related SAEs ‐ pain crisis compared with standard care (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs usual care

Proportion of participants developing new or progressive SCI lesions · prevention of SCI in people with SCD and abnormal TCD velocities

Long‐term RBC transfusion may leads to lower proportion of participants developing new or progressive SCI lesions compared with standard care (low certainty).

1 finding from 1 review