Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 32 findings · 5 reviews · Skin · Headline outcomes only

No studies found 4 · 12.5%GRADE not reported 0 · 0%Very low 7 · 21.9%Low 16 · 50%Moderate 5 · 15.6%High 0 · 0%

Salt bath + UVB vs UVB alone

Number of adverse events requiring discontinuation of treatment ‐ not reported · people with chronic plaque psoriasis

Salt bath + UVB showed no clear difference in treatment‐related adverse events requiring withdrawal (number of… compared with UVB alone (low certainty).

1 finding from 1 review

Topical active treatment in combination with moisturiser vs topical active treatment alone

Number of participants reporting an adverse event · people with eczema

It is very uncertain whether topical active treatment in combination with moisturiser changes number of participants reporting an adverse event compared with topical active treatment alone (very low certainty).

1 finding from 1 review

Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg

Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism

Flutamide 250 mg once to b.i.d. showed no clear difference in participant‐reported improvement of hirsutism 4‐point Likert scale compared with spironolactone 100 mg (low certainty).

1 finding from 1 review

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg

Proportion of participants who reported an adverse event · patients with hirsutism

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg showed no clear difference in proportion of participants who reported an adverse event compared with ethinyl estradiol 30 μg + desogestrel 0.15 mg (moderate certainty).

1 finding from 1 review