Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 12 findings · 2 reviews · Infectious Diseases · Headline outcomes only

No studies found 0 · 0%GRADE not reported 1 · 8.3%Very low 4 · 33.3%Low 3 · 25%Moderate 3 · 25%High 1 · 8.3%

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with severe haemolysis · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg showed no clear difference in participants with severe haemolysis compared with no primaquine, with artemisinin partner, (low certainty).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 4‐5, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.4 to 0.5 mg/kg showed no clear difference in participants with gametocytes at day 4‐5, by microscopy compared with no primaquine, with non‐artemisinin partner, (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 8, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.4 to 0.5 mg/kg probably leads to lower participants with gametocytes at day 8, by microscopy compared with no primaquine, with non‐artemisinin partner, (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants infectious at day 8 · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg may leads to lower participants infectious at day 3‐4 compared with no primaquine, with artemisinin partner, (low certainty).

2 findings from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 3‐4, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg showed no clear difference in participants with gametocytes at day 3‐4, by PCR compared with no primaquine, with artemisinin partner, (moderate certainty).

1 finding from 1 review

Single dose primaquine at 0.4 to 0.5 mg/kg vs no primaquine, with artemisinin partner,

Participants with gametocytes at day 8, by PCR · adults and children with malaria being treated with artemisinin combination treatment

Single dose primaquine at 0.4 to 0.5 mg/kg leads to lower participants with gametocytes at day 8, by PCR compared with no primaquine, with artemisinin partner, (high certainty).

1 finding from 1 review

Intervention not reported

False positives (participants incorrectly classified as having pneumonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults and children with…
1 finding from 1 review

Intervention not reported

Test result · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults and children with…
1 finding from 1 review

Intervention not reported

True positives (participants correctly classified as having pneumonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults and children with…
1 finding from 1 review

Intervention not reported

False negatives (participants incorrectly classified as not having pneumonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults and children with…
1 finding from 1 review

Intervention not reported

True negatives (participants correctly classified as not having pneumonic plague) · s where plague has been known to occur and populations where an outbreak is in progress Patient or population: adults and children with…
1 finding from 1 review