Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 2 reviews · Hepato-Biliary

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 8 · 72.7%Low 3 · 27.3%Moderate 0 · 0%High 0 · 0%

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Hepatotoxicity · people with paracetamol (acetaminophen) overdose

It is very uncertain whether standard intravenous acetylcysteine regimen (20.5 hour) changes hepatotoxicity compared with shorter intravenous acetylcysteine regimen (12 hour) (very low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Vomiting, retching, or antiemetics from 0‐2 hours · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics from 0‐2 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Vomiting, retching, or antiemetics 0‐12 hours · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics 0‐12 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Anaphylactoid symptoms · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower anaphylactoid symptoms compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review

Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL

Re‐bleeding Bleeding after initial success in the intervention · acute bleeding gastric varices in people with portal hypertension

It is very uncertain whether cyanoacrylate 1 mL changes re‐bleeding Bleeding after initial success in the intervention compared with cyanoacrylate 0.5 mL (very low certainty).

1 finding from 1 review

Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL

Control of bleeding Success in control the active variceal bleeding · acute bleeding gastric varices in people with portal hypertension

It is very uncertain whether cyanoacrylate 1 mL changes control of bleeding Success in control the active variceal bleeding compared with cyanoacrylate 0.5 mL (very low certainty).

1 finding from 1 review

Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL

Total mortality Total deaths and the end of · acute bleeding gastric varices in people with portal hypertension

It is very uncertain whether cyanoacrylate 1 mL changes total mortality Total deaths and the end of compared with cyanoacrylate 0.5 mL (very low certainty).

1 finding from 1 review

Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL

day ‐ mortality Mortality due to bleeding · acute bleeding gastric varices in people with portal hypertension

It is very uncertain whether cyanoacrylate 1 mL changes day ‐ mortality Mortality due to bleeding compared with cyanoacrylate 0.5 mL (very low certainty).

1 finding from 1 review

Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL

Failure of intervention Continuous bleeding after intervention · acute bleeding gastric varices in people with portal hypertension

It is very uncertain whether cyanoacrylate 1 mL changes failure of intervention Continuous bleeding after intervention compared with cyanoacrylate 0.5 mL (very low certainty).

1 finding from 1 review

Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL

Complications (fever) Presence of fever · acute bleeding gastric varices in people with portal hypertension

It is very uncertain whether cyanoacrylate 1 mL changes complications (fever) Presence of fever compared with cyanoacrylate 0.5 mL (very low certainty).

1 finding from 1 review