Findings

What do systematic reviews say?

32 questions · 33 findings · 6 reviews · Headline outcomes only

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No studies found 3 · 9.1%GRADE not reported 1 · 3%Very low 12 · 36.4%Low 15 · 45.5%Moderate 2 · 6.1%High 0 · 0%

'Other' antidepressants vs placebo

Quality of sleep · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 370 participants
Moderate

'Other' antidepressants vs placebo

Adverse events · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 217 participants
Low

'Other' antidepressants vs placebo

Sleep efficiency · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 169 participants
Low

Antidepressants vs any other pharmacological intervention

Depression response (acute phase, 5 ≤ 12 weeks) · women of any age, with PND up to 12 months

It is very uncertain whether antidepressants changes depression response (acute phase, 5 ≤ 12 weeks) compared with any other pharmacological intervention (very low certainty).

1 finding from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
RR 0.98 [0.76, 1.27]
Studies not reported
Very low

Antidepressants vs any other pharmacological intervention

Depression remission · women of any age, with PND up to 12 months

It is very uncertain whether antidepressants changes depression remission (acute phase, 5 ≤ 12 weeks) compared with any other pharmacological intervention (very low certainty).

2 findings from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
RR 0.98 [0.68, 1.41]
Studies not reported
Very low
Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Antidepressants vs any other pharmacological intervention

Adverse events · women of any age, with PND up to 12 months

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs any other pharmacological intervention

Depression response (early phase, < 5 weeks) · women of any age, with PND up to 12 months

1 finding from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Antidepressants vs any other pharmacological intervention

Depression severity (acute phase, 5 ≤ 12 weeks) · women of any age, with PND up to 12 months

1 finding from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Antidepressants vs any other pharmacological intervention

Acceptability ‐ total dropouts · women of any age, with PND up to 12 months

It is very uncertain whether antidepressants changes treatment acceptability ‐dropouts compared with any other pharmacological intervention (very low certainty).

1 finding from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
RR 1.74 [0.99, 3.06]
Studies not reported
Very low

Antidepressants vs any other pharmacological intervention

Child‐related outcomes · women of any age, with PND up to 12 months

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tricyclic antidepressants vs another medication

Severity/intensity of MUPS (post‐treatment score on self report scales) Different self report scales (VAS‐Pain, SCL‐90‐R Somatisation Subscore) · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 177 participants
Low

Tricyclic antidepressants vs another medication

Acceptability · somatoform disorders in adults

Tricyclic antidepressants showed no clear difference in acceptability (all‐cause drop‐outs4) compared with another medication (low certainty).

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
RR 1.48 [0.59, 3.72]
8 studies · 556 participants
Low

Tricyclic antidepressants vs another medication

Anxiety · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 255 participants
Very low

Tricyclic antidepressants vs another medication

Depression (post‐treatment score on self report and clinician‐rated scales) Different self report and clinician‐rated scales (HDRS, BDI) · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 395 participants
Low

Tricyclic antidepressants vs another medication

Adverse effects (drop‐outs due to adverse effects4) · somatoform disorders in adults

Tricyclic antidepressants showed no clear difference in adverse effects (drop‐outs due to adverse effects4) compared with another medication (low certainty).

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
RR 2.37 [0.39, 14.28]
8 studies · 556 participants
Low

Tricyclic antidepressants vs another medication

Treatment response (post‐treatment score on self report and clinician‐rated scales) · somatoform disorders in adults

Tricyclic antidepressants showed no clear difference in treatment response (post‐treatment score on self report and… compared with another medication (low certainty).

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
RR 0.93 [0.73, 1.19]
2 studies · 130 participants
Low

Tricyclic antidepressants vs another medication

Quality of life at post‐treatment Indexed by self‐report measures of quality of life or functional disability · somatoform disorders in adults

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse effects experienced by mother and/or foetus or nursing baby · women with a history of postnatal depression

1 finding from 1 review

Antidepressants for preventing postnatal depression 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 51 participants
Very low

Intervention not reported

Adverse effects experienced by mother and/or fetus or nursing baby · women with a history of postnatal depression

1 finding from 1 review

Antidepressants for preventing postnatal depression 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Selective serotonin reuptake inhibitors vs placebo

Other subjective measures of sleep (total sleep time, sleep onset latency, nocturnal awakenings and subjective sleep efficiency) (PSQI) (at 12 weeks) · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Very low