Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy

Voice (Voice Handicap Index) · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

Standard‐dose adjuvant radiotherapy alone vs adjuvant chemoradiotherapy

Voice (Voice Handicap Index) · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Major bleeding, requiring transfusion of packed red blood cells · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in major bleeding requiring transfusion of packed red blood cells compared with placebo (placebo solution/mouthwash); GRADE not reported.

1 finding from 1 review