Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Manipulation (cervical) vs oral medicine

Acute and subacute neck pain Intermediate‐term · patients with acute and subacute neck pain

Manipulation (cervical) showed no clear difference in acute and subacute neck pain Intermediate‐term compared with oral medicine (moderate certainty).

1 finding from 1 review

Intervention not reported

Although a higher percentage of people in the ATL and aCCT groups fell within Class I (seizure free) and Class II (> 50% reduction in seizures), no significant differences in seizure frequency were noted between the groups at 2 years after surgery... · people with temporal lobe epilepsy and intellectual disabilities
1 finding from 1 review

Intravenous iron vs oral iron

All gastrointestinal symptoms Reported by the women · women with postpartum iron deficiency anaemia

It is very uncertain whether intravenous iron changes all gastrointestinal symptoms Reported by the women compared with oral iron (very low certainty).

1 finding from 1 review

Intravenous iron vs oral iron

Anaphylaxis or evidence of hypersensitivity Clinical assessment · women with postpartum iron deficiency anaemia

Intravenous iron showed no clear difference in anaphylaxis or evidence of hypersensitivity Clinical assessment compared with oral iron (low certainty).

1 finding from 1 review

Treatment route: intravenous corticosteroid vs oral corticosteroid

Mortality after discharge (1‐3 months) · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in mortality after discharge (1‐3 months) compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Treatment route: intravenous corticosteroid vs oral corticosteroid

Treatment failure Need for additional treatment · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in treatment failure Need to intensify therapy compared with oral corticosteroid (moderate certainty).

1 finding from 1 review