Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,696 questions · 3,815 findings · 855 reviews

No studies found 573 · 15%GRADE not reported 374 · 9.8%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Intervention not reported

Maternal length of hospital stay (days) · pregnant women and their infants

The intervention showed no clear difference in maternal length of hospital stay (days) (low certainty).

1 finding from 1 review

Intervention not reported

Infant length of hospital stay (days) · pregnant women and their infants

The intervention showed no clear difference in infant length of hospital stay (days) (low certainty).

1 finding from 1 review

Intervention not reported

Quality of life: Days of work lost per crisis · adults and children with sickle cell disease

The intervention showed no clear difference in quality of life: Days of work lost per crisis (moderate certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

Acute stroke (within 30‐days after surgery: new focal neurologic deficit with signs and symptoms lasting longer than 24 hours) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists may leads to lower acute stroke (within 30‐days after surgery: new focal neurologic… compared with control (low certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

All‐cause mortality (within 30‐days after surgery: any reported death) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists showed no clear difference in all‐cause mortality (within 30‐days after surgery: any reported death) compared with control (moderate certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

Myocardial infarction (within 30‐days after surgery: sudden death or death resulting from a primarily identifiable cardiac cause) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists showed no clear difference in myocardial infarction (within 30‐days after surgery: sudden death or… compared with control (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo + standard care

Control of epistaxis: episodes of re‐bleeding over 10 days All treatments (topical and oral) · adults with nasal haemorrhage (epistaxis)

Tranexamic acid probably leads to lower control of epistaxis: episodes of re‐bleeding over 10 days All… compared with placebo plus usual care or usual care alone (moderate certainty).

1 finding from 1 review