Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,359 questions · 2,491 findings · 249 reviews

No studies found 696 · 27.9%GRADE not reported 213 · 8.6%Very low 611 · 24.5%Low 595 · 23.9%Moderate 315 · 12.6%High 61 · 2.4%

Vedolizumab vs placebo

Improved IBDQ at week 52 · people with active UC

Vedolizumab probably leads to higher improved IBDQ at week 6 compared with placebo (moderate certainty).

2 findings from 1 review

TNF‐alpha antagonists vs placebo

IBDQ at weeks 6 or 8 · people with active UC

TNF‐alpha antagonists leads to higher improved IBDQ at weeks 6 or 8 compared with placebo (high certainty).

2 findings from 1 review