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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

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No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Neoadjuvant immunotherapy (talimogene laherparepvec) vs no neoadjuvant treatment

Time to recurrence · stage III and IV cutaneous melanoma

It is very uncertain whether neoadjuvant immunotherapy (talimogene laherparepvec) changes time to recurrence (TTR), measured by the number of disease… compared with no neoadjuvant treatment (very low certainty).

1 finding from 1 review

Serenoa repens in combination with other phytotherapy vs placebo or no intervention

Urologic symptom scores · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Serenoa repens in combination with other phytotherapy showed no clear difference in urologic symptom scoreMeasured by IPSS scores (range 0 to 35)Higher… compared with placebo or no intervention (low certainty).

1 finding from 1 review

Serenoa repens in combination with other phytotherapy vs placebo or no intervention

Adverse eventsCumulative incidence · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Serenoa repens in combination with other phytotherapy showed no clear difference in adverse eventsCumulative incidence compared with placebo or no intervention (low certainty).

1 finding from 1 review

Multi‐systemic therapy involving family and juveniles vs treatment

Arrested · drug‐using offenders with co‐occurring mental health problems

Multi‐systemic therapy involving family and juveniles showed no clear difference in arrested assessed by corroborating with police data compared with treatment (low certainty).

1 finding from 1 review

Full‐mouth ultrasonic scaling plus photodynamic therapy vs full‐mouth ultrasonic scaling alone

Resolution or reduction in severity of any other dental complication: reduction in severity of periodontitis (measured by reduction in clinical attachment loss) · people with thalassaemia (any age)

The review found no eligible studies for this question.

1 finding from 1 review

Full‐mouth ultrasonic scaling plus photodynamic therapy vs full‐mouth ultrasonic scaling alone

Resolution or reduction in severity of any other dental complication: oral infections (measured by reduction in or resolution of lesions such as periapical cysts, abscesses, or space infections) · people with thalassaemia (any age)

The review found no eligible studies for this question.

1 finding from 1 review

Full‐mouth ultrasonic scaling plus photodynamic therapy vs full‐mouth ultrasonic scaling alone

Resolution or reduction in severity of any other dental complication: systemic infections (measured by number of episodes after treatment for dental complications under antibiotic prophylaxis) · people with thalassaemia (any age)

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Other therapies (cryotherapy) vs other therapies (fractional CO2 laser)

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

It is very uncertain whether summary of findings table ‐ Other therapies (cryotherapy) changes short‐term hair regrowth ≥ 75% compared with other therapies (fractional CO2 laser) (very low certainty).

1 finding from 1 review