Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Edaravone plus corticosteroids vs corticosteroids

Reduction in oedema (T2 hyperintensity) · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

Edaravone plus corticosteroids showed no clear difference in reduction in oedema (T2 hyperintensity) compared with corticosteroids (low certainty).

1 finding from 1 review

Edaravone plus corticosteroids vs corticosteroids

Reduction in post‐gadolinium enhancement · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

Edaravone plus corticosteroids showed no clear difference in reduction in post‐gadolinium enhancement compared with corticosteroids (low certainty).

1 finding from 1 review

Edaravone plus corticosteroids vs corticosteroids

Improvement in LENT/SOMA · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

Edaravone plus corticosteroids may leads to higher improvement in LENT/SOMA compared with corticosteroids (low certainty).

1 finding from 1 review

Sinonasal debridement vs no debridement

Significant adverse effects: significant bleeding requiring intervention, severe pain, iatrogenic injury · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

The review found no eligible studies for this question.

1 finding from 1 review

Sinonasal debridement vs no debridement

Postoperative endoscopic appearance of the sinonasal surgical cavities: Lund‐Kennedy endoscopic score (range 1 to 10) · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

Sinonasal debridement showed no clear difference in postoperative endoscopic appearance of the sinonasal surgical… compared with no debridement (low certainty).

1 finding from 1 review

Sinonasal debridement vs no debridement

Adhesion rate · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

Sinonasal debridement may leads to lower adhesion rate compared with no debridement (low certainty).

1 finding from 1 review

Local anaesthetic injection vs no treatment/placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · septal surgery

The review found no eligible studies for this question.

3 findings from 1 review

Local anaesthetic application via nasal packing vs no packing/packing with placebo

Additional analgesia required (escape analgesia) · septal surgery

Local anaesthetic application via nasal packing probably leads to lower requirement for additional analgesia compared with no packing/packing with placebo (moderate certainty).

1 finding from 1 review