Comparison 13: SSRIs vs placebo
Comparison 6: SSRIs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).
- RR 0.98 [0.96, 1]14 studies · 2399 participantsModerate
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Comparison 6: SSRIs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).
Comparison 7: TCAs may leads to lower treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (low certainty).
Comparison 7: TCAs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).
Comparison 1: Alpha‐blockers showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).
It is very uncertain whether comparison 2: Antipsychotics changes treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (very low certainty).
Comparison 2: Antipsychotics showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).
The review found no eligible studies for this question.
Comparison 3: MAOIs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).
Comparison 4: NaSSAs may leads to lower treatment efficacy ‐ Treatment response, as measured by the Global… compared with placebo (low certainty).
Comparison 4: NaSSAs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).
The review found no eligible studies for this question.
Aspirin showed no clear difference in total mortality compared with placebo (low certainty).
Aspirin showed no clear difference in cardiovascular mortality compared with placebo (low certainty).
Aspirin may leads to lower non‐fatal cardiovascular events compared with placebo (low certainty).
Aspirin leads to higher major bleedinga compared with placebo (high certainty).
Aspirin may leads to lower all cardiovascular events compared with placebo (low certainty).
It is very uncertain whether pharmaceutical interventions changes emotionalism (primary outcome) compared with placebo (very low certainty).