Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Comparison 7: TCAs vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults (aged 18‐85)

Comparison 7: TCAs may leads to lower treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (low certainty).

1 finding from 1 review

Alpha‐blockers vs placebo

Dropouts due to adverse events · adults (aged 18‐85)

Comparison 1: Alpha‐blockers showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Antipsychotics vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults (aged 18‐85)

It is very uncertain whether comparison 2: Antipsychotics changes treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (very low certainty).

1 finding from 1 review

Antipsychotics vs placebo

Dropouts due to adverse events · adults (aged 18‐85)

Comparison 2: Antipsychotics showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).

1 finding from 1 review

MAOIs vs placebo

Dropouts due to adverse events · adults (aged 18‐85)

Comparison 3: MAOIs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).

1 finding from 1 review

Comparison 9: NaSSAs vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults (aged 18‐85)

Comparison 4: NaSSAs may leads to lower treatment efficacy ‐ Treatment response, as measured by the Global… compared with placebo (low certainty).

1 finding from 1 review

Aspirin vs placebo

Total mortality · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin showed no clear difference in total mortality compared with placebo (low certainty).

1 finding from 1 review

Aspirin vs placebo

Cardiovascular mortality · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin showed no clear difference in cardiovascular mortality compared with placebo (low certainty).

1 finding from 1 review

Aspirin vs placebo

Non‐fatal cardiovascular events · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin may leads to lower non‐fatal cardiovascular events compared with placebo (low certainty).

1 finding from 1 review

Aspirin vs placebo

Major bleedinga · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin leads to higher major bleedinga compared with placebo (high certainty).

1 finding from 1 review

Aspirin vs placebo

Cardiovascular events · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin may leads to lower all cardiovascular events compared with placebo (low certainty).

1 finding from 1 review