Postoperative complications (infection) / adverse events · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…
1 finding from 1 review
No particular adverse events or infection attributable to EMD in any trial; no differences in pain, edema, hematoma, wound dehiscence or root sensitivity (Tonetti 2002).
9 studies
GRADE not reported
PAL gain < 2 mm (dichotomous) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…
Enamel matrix derivative (EMD; Emdogain) led to lower PAL gain < 2 mm (dichotomous) compared with placebo or control (same surgical or non-surgical intervention…; GRADE not reported.
1 finding from 1 review
RR 0.53 [0.34, 0.82]
6 studies
GRADE not reported
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Intralesional steroid injection plus adjunctive treatment showed no clear difference in maximal mouth opening (interincisal distance) compared with intralesional steroid injection alone (low certainty).
2 findings from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether buccal fat pad pedicle plus placental extract changes maximal mouth opening (interincisal distance) compared with buccal fat pad pedicle alone (very low certainty).
1 finding from 1 review
Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events associated with treatment · Adults with oropharyngeal cancer
1 finding from 1 review
Adverse events: grade 2+ treatment-related events similar (31/34 radiotherapy vs 33/34 surgery; RR 0.94, 0.83 to 1.06); more hearing loss/neutropenia/constipation/tinnitus with radiotherapy, more oral bleeding/trismus…
1 study · 68 participants
Very low
Total mortality · Adults with oral cavity or oropharyngeal cancer
It is very uncertain whether surgery plus radiotherapy changes total mortality compared with radiotherapy alone (very low certainty).
1 finding from 1 review
Disease-free survival · Adults with oral cavity or oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
Total mortality · Adults with oropharyngeal cancer
Surgery showed no clear difference in total mortality compared with radiotherapy alone (low certainty).
1 finding from 1 review
Locoregional recurrence · Adults with oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
Recurrence · Adults with oral cavity or oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
Disease control (healing of skin lesions) at day 21 · bullous pemphigoid
Clobetasol propionate cream probably leads to higher disease control (healing of skin lesions) at day 21 compared with oral prednisone (moderate certainty).
1 finding from 1 review
Treatment‐related mortality at 1 year (mITT) · bullous pemphigoid
Doxycycline probably leads to lower treatment‐related mortality at 1 year (mITT) compared with prednisolone (moderate certainty).
1 finding from 1 review
Quality of life (DLQI) adjusted for baseline DLQI, disease severity, age, Karnovsky score, baseline versus week 52. A lower score is more favourable. · bullous pemphigoid
1 finding from 1 review
Number of participants with grade 3‐4 (severe or life‐threatening) treatment‐related adverse events at 1 year (raw data) · bullous pemphigoid
Doxycycline probably leads to lower number of participants with grade 3‐4 (severe or life‐threatening)… compared with prednisolone (moderate certainty).
1 finding from 1 review
Disease control: complete response at 8 weeks: excluding dropouts · bullous pemphigoid
It is very uncertain whether nicotinamide plus tetracycline changes disease control: complete response at 8 weeks: excluding dropouts compared with prednisone (very low certainty).
1 finding from 1 review
Mortality at 6 months · bullous pemphigoid
It is very uncertain whether nicotinamide plus tetracycline changes mortality at 6 months compared with prednisone (very low certainty).
1 finding from 1 review
Quality of life ‐ not measured · bullous pemphigoid
The review found no eligible studies for this question.
1 finding from 1 review
Mortality at 1 year · bullous pemphigoid
Clobetasol propionate cream showed no clear difference in mortality at 1 year compared with oral prednisone (low certainty).
1 finding from 1 review
Adverse events at 1 year · bullous pemphigoid
1 finding from 1 review