Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Intervention not reported

Hemiarthroplasty (No direct evidence, indirect evidence only) · older adults (> 60 years of age) with extracapsular hip fractures

It is very uncertain whether the intervention changes hemiarthroplasty (No direct evidence, indirect evidence only) (very low certainty).

1 finding from 1 review

Intervention not reported

Static fixed angle plate (5 studies; 847 participants)a · older adults (> 60 years of age) with extracapsular hip fractures

It is very uncertain whether the intervention changes static fixed angle plate (5 studies; 847 participants)a (very low certainty).

1 finding from 1 review

Intervention not reported

Long cephalomedullary nail (2 studies; 400 participants)a · older adults (> 60 years of age) with extracapsular hip fractures

It is very uncertain whether the intervention changes long cephalomedullary nail (2 studies; 400 participants)a (very low certainty).

1 finding from 1 review

Intervention not reported

Short cephalomedullary nail (33 studies; 5380 participants)a · older adults (> 60 years of age) with extracapsular hip fractures

It is very uncertain whether the intervention changes short cephalomedullary nail (33 studies; 5380 participants)a (very low certainty).

1 finding from 1 review

Intervention not reported

Hemiarthroplasty (No direct evidence, indirect evidence only) · older adults (> 60 years of age) with extracapsular hip fractures

It is very uncertain whether the intervention changes hemiarthroplasty (No direct evidence, indirect evidence only) (very low certainty).

1 finding from 1 review

Tocilizumab every 4 weeks vs placebo

Proportion of participants with sustained remission (as defined by study investigators) at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab every 4 weeks probably leads to higher proportion of participants with sustained remission (as defined by… compared with placebo (moderate certainty).

1 finding from 1 review

Tocilizumab every 4 weeks vs placebo

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab every 4 weeks showed no clear difference in adverse events at ≥ 12 months compared with placebo (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 52‐week taper

Proportion of participants with sustained remission (as defined by study investigators) at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly probably leads to higher proportion of participants with sustained remission (as defined by… compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 52‐week taper

Proportion of participants with relapse‐free survival at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly probably leads to higher proportion of participants with relapse‐free survival at ≥ 12 months compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 52‐week taper

Proportion of participants who did not need escape therapy (as defined by study investigators) · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly probably leads to higher proportion of participants who did not need escape therapy (as… compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review