Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,209 questions · 2,322 findings · 227 reviews · Headline outcomes only

No studies found 644 · 27.7%GRADE not reported 135 · 5.8%Very low 591 · 25.5%Low 582 · 25.1%Moderate 309 · 13.3%High 61 · 2.6%

Vedolizumab vs placebo

Improved IBDQ at week 52 · people with active UC

Vedolizumab probably leads to higher improved IBDQ at week 6 compared with placebo (moderate certainty).

2 findings from 1 review

TNF‐alpha antagonists vs placebo

IBDQ at weeks 6 or 8 · people with active UC

TNF‐alpha antagonists leads to higher improved IBDQ at weeks 6 or 8 compared with placebo (high certainty).

2 findings from 1 review