Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,539 questions · 2,602 findings · 424 reviews · Headline outcomes only

No studies found 572 · 22%GRADE not reported 189 · 7.3%Very low 527 · 20.3%Low 685 · 26.3%Moderate 514 · 19.8%High 115 · 4.4%

Paliperidone palmitate vs risperidone long‐acting injection

No clinically important change Number of people whose PANSS score either increased or did not decrease by at least 30% from the beginning to the end of the trial · patients with schizophrenia

Paliperidone palmitate showed no clear difference in no clinically important change Number of people whose PANSS score… compared with risperidone long‐acting injection (low certainty).

1 finding from 1 review

Paliperidone palmitate vs risperidone long‐acting injection

Relapse: recurrence of psychotic symptoms Reported by trial author as adverse event · patients with schizophrenia

Paliperidone palmitate showed no clear difference in relapse: recurrence of psychotic symptoms Reported by trial authors… compared with risperidone long‐acting injection (moderate certainty).

1 finding from 1 review

Paliperidone palmitate vs risperidone long‐acting injection

Leaving the study early ‐ lack of efficacy Reported by trial author · patients with schizophrenia

Paliperidone palmitate probably leads to higher leaving the study early ‐ lack of efficacy Reported by trial author compared with risperidone long‐acting injection (moderate certainty).

1 finding from 1 review

Summary of findings: insulin detemir vs NPH insulin

All‐cause mortality
2 findings from 2 reviews · compare the 2 reviews

Summary of findings: insulin detemir vs NPH insulin

Health‐related quality of life
2 findings from 2 reviews · compare the 2 reviews

Summary of findings: insulin detemir vs NPH insulin

HbA1c (%)
2 findings from 2 reviews · compare the 2 reviews