Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,970 questions · 2,433 findings · 231 reviews

No studies found 303 · 12.5%GRADE not reported 759 · 31.2%Very low 357 · 14.7%Low 476 · 19.6%Moderate 418 · 17.2%High 120 · 4.9%

ASA with LMWH vs placebo or IVIG

Bleeding ‐ major (bleeding requiring transfusion) Length of · people with antiphospholipid antibodies and no history of thrombosis

ASA with LMWH showed no clear difference in bleeding ‐ major (bleeding requiring transfusion) Length of compared with placebo or IVIG (moderate certainty).

1 finding from 1 review

ASA with LMWH vs placebo or IVIG

Bleeding ‐ other (bleeding during first trimester) Length of · people with antiphospholipid antibodies and no history of thrombosis

ASA with LMWH showed no clear difference in bleeding ‐ other (bleeding during first trimester) Length of compared with placebo or IVIG (moderate certainty).

1 finding from 1 review

ASA with LMWH vs placebo or IVIG

Bleeding ‐ other (postpartum haemorrhage) Length of · people with antiphospholipid antibodies and no history of thrombosis

ASA with LMWH showed no clear difference in bleeding ‐ other (postpartum haemorrhage) Length of compared with placebo or IVIG (moderate certainty).

1 finding from 1 review