Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Intervention not reported

Vessel patency at 30 days · patients seeking treatment for initial management of acute limb ischaemia

It is very uncertain whether the intervention changes vessel patency at 30 days (very low certainty).

1 finding from 1 review

Intervention not reported

Major haemorrhage at 30 days · patients seeking treatment for initial management of acute limb ischaemia

The intervention may leads to higher major haemorrhage at 30 days (low certainty).

1 finding from 1 review

Intervention not reported

Stroke at 30 days · patients seeking treatment for initial management of acute limb ischaemia

The intervention showed no clear difference in stroke at 30 days (low certainty).

1 finding from 1 review

Intervention not reported

Distal embolisation at 30 days · patients seeking treatment for initial management of acute limb ischaemia

It is very uncertain whether the intervention changes distal embolisation at 30 days (very low certainty).

1 finding from 1 review

Intervention not reported

Maternal length of hospital stay (days) · pregnant women and their infants

The intervention showed no clear difference in maternal length of hospital stay (days) (low certainty).

1 finding from 1 review

Intervention not reported

Infant length of hospital stay (days) · pregnant women and their infants

The intervention showed no clear difference in infant length of hospital stay (days) (low certainty).

1 finding from 1 review

Intervention not reported

Quality of life: Days of work lost per crisis · adults and children with sickle cell disease

The intervention showed no clear difference in quality of life: Days of work lost per crisis (moderate certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

Acute stroke (within 30‐days after surgery: new focal neurologic deficit with signs and symptoms lasting longer than 24 hours) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists may leads to lower acute stroke (within 30‐days after surgery: new focal neurologic… compared with control (low certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

All‐cause mortality (within 30‐days after surgery: any reported death) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists showed no clear difference in all‐cause mortality (within 30‐days after surgery: any reported death) compared with control (moderate certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

Myocardial infarction (within 30‐days after surgery: sudden death or death resulting from a primarily identifiable cardiac cause) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists showed no clear difference in myocardial infarction (within 30‐days after surgery: sudden death or… compared with control (moderate certainty).

1 finding from 1 review