Findings

What do systematic reviews say?

1,954 questions · 2,335 findings · 149 reviews · All outcomes

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No studies found 436 · 18.7%GRADE not reported 1,370 · 58.7%Very low 254 · 10.9%Low 173 · 7.4%Moderate 80 · 3.4%High 22 · 0.9%

Tranexamic acid (AMCA cones) vs Placebo (lactose cones)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Tranexamic acid (AMCA cones) showed no clear difference in presence of dry socket compared with placebo (lactose cones); GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.67 [0.30, 1.48]
1 study · 120 participants
GRADE not reported

Clindamycin phosphate antibiotic solution patch vs Saline patch

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
OR (exact) 0 [0, 0.69]
1 study · 86 participants
GRADE not reported

Apernyl (acetylsalicylic acid pellet) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Apernyl (acetylsalicylic acid pellet) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.25 [0.03, 2.16]
1 study · 100 participants
GRADE not reported

Advanced platelet rich fibrin (A-PRF) vs No active treatment (control)

Pain (VAS cm) · Adults (>18 years) with established dry socket following permanent tooth extraction

Advanced platelet rich fibrin (A-PRF) led to lower pain (VAS cm) compared with control (no treatment); GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Days 1-7 (day 7 shown)
MD -3.60 [-4.00, -3.20]
1 study · 40 participants
GRADE not reported

Chlorhexidine gel (0.2%, intrasocket) vs Chlorhexidine mouthrinse

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
No adverse events were reported in these two trials (Abu-Mostafa 2015; Hita-Iglesias 2008).
2 studies
GRADE not reported

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Swelling (mean) · Adults (>18 years) with established dry socket following permanent tooth extraction

The review found no eligible studies for this question.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
No studies reported this outcome
0 studies
No studies found

SaliCept (acemannan hydrogel) vs no treatment

Pain (VAS) · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
SaliCept (acemannan hydrogel) versus No treatment (Kaya 2011): data not usable (medians presented with error bars). Text reports differences in clinical signs and symptoms between control and all 3 treatment groups…
1 study
GRADE not reported

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Fever · Adults (>18 years) with established dry socket following permanent tooth extraction

The review found no eligible studies for this question.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
No studies reported this outcome
0 studies
No studies found

Plasma rich in growth factors (PRGF) vs Alvogyl

Exposed bone (present versus absent) · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Day 7 (also day 3)
PRGF versus Alvogyl (King 2018), exposed bone (% patients): day 3 PRGF 9.1% vs Alvogyl 9.1%; day 7 PRGF 0% vs Alvogyl 22.7% (P<0.05 at day 7)
1 study · 44 participants
GRADE not reported

Alvogyl vs SaliCept (acemannan hydrogel)

Pain (VAS) · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Alvogyl versus SaliCept (acemannan hydrogel) (Kaya 2011): data not usable (medians presented with error bars). Text reports differences in clinical signs and symptoms between control and all 3 treatment groups…
1 study
GRADE not reported

Neocone vs Alvogyl

Mean time to resolution of pain · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to lower time to complete resolution of pain (days) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Complete resolution of pain
MD -1.62 [-1.86, -1.38]
1 study · 78 participants
GRADE not reported

Alvogyl vs Zinc oxide and eugenol (ZOE)

Mean time to resolution of pain · Adults (>18 years) with established dry socket following permanent tooth extraction

Alvogyl led to lower time to complete resolution of pain (days) compared with zinc oxide eugenol; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Complete resolution of pain
MD -2.17 [-2.37, -1.97]
1 study · 78 participants
GRADE not reported

P-hydroxybenzoic acid vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

P-hydroxybenzoic acid showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.08 [0.00, 1.37]
1 study · 45 participants
GRADE not reported

Heal-all tissue patch vs no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Heal-all tissue patch showed no clear difference in presence of dry socket compared with no treatment; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.08 [0.00, 1.32]
1 study · 80 participants
GRADE not reported

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) probably leads to lower presence of dry socket compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
OR 0.38 [0.25, 0.58]
6 studies · 1547 participants
Moderate

Gaseous ozone vs placebo or control

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Gaseous ozone showed no clear difference in presence of dry socket compared with placebo or control; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.20 [0.02, 1.61]
1 study · 60 participants
GRADE not reported

Artemisia desertorum spreng (Shahaosan) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Artemisia desertorum spreng (Shahaosan) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.13 [0.02, 1.02]
1 study · 188 participants
GRADE not reported

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Healing: 2 studies (Faizel 2015; Supe 2018) used different healing outcomes and could not be combined; Alvogyl appeared to heal faster than zinc oxide eugenol. Supe 2018: delayed (non-healed after 10 days) 2/25 Alvogyl…
2 studies
GRADE not reported

Alvogyl vs Platelet-rich fibrin (PRF)

Pain · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Alvogyl versus platelet rich fibrin (Keshini 2020): single study (30 participants); no usable pooled estimate extracted
1 study · 30 participants
GRADE not reported

Metronidazole (intrasocket) vs placebo

Duration of treatment (days) · Adults (>18 years) with established dry socket following permanent tooth extraction

Metronidazole (intrasocket) led to lower duration of treatment (days) compared with placebo; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
MD -3.17 [-5.30, -1.04]
1 study · 55 participants
GRADE not reported