What do systematic reviews say?

Decrease in heart rate · Adults with primary hypertension

Decrease in pulse pressure · Adults with primary hypertension

Withdrawal due to adverse effect · Adults with primary hypertension

SBP (mmHg) · adults with primary hypertension

Diastolic blood pressure · adults with primary hypertension

Heart rate · adults with primary hypertension

Pulse pressure · adults with primary hypertension

Withdrawals due to adverse events · adults with primary hypertension

High‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

High‐ versus medium‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

Medium‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

High‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

High‐ versus medium‐ dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

Medium‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

High‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

High‐ versus medium‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

Medium‐ versus low‐dose · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

High vs low dose Systolic blood pressure · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

High vs low dose Diastolic blood pressure · children (from 1 to 18 years of age) with hypertension from primary or secondary causes

Overall survival · patients with extensive SCLC without previous treatment