Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,061 questions · 2,151 findings · 116 reviews

No studies found 609 · 28.3%GRADE not reported 268 · 12.5%Very low 635 · 29.5%Low 491 · 22.8%Moderate 122 · 5.7%High 26 · 1.2%

Intervention not reported

Improvement in heart rate · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Duration of hospitalisation · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Clinically important adverse events · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Patient satisfaction · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia

The review found no eligible studies for this question.

1 finding from 1 review

Experimental chewing adjuncts (bite wafers or chewing gum) vs No chewing gum, placebo, or control (no adjunct)

Quality of life or patient satisfaction · Adolescents/teenagers undergoing orthodontic treatment

Experimental chewing adjuncts (bite wafers or chewing gum) led to lower quality of life or patient satisfaction compared with no chewing gum, placebo, or control (no adjunct); GRADE not reported.

1 finding from 1 review

Experimental chewing adjuncts (bite wafers or chewing gum) vs No chewing gum, placebo, or control (no adjunct)

Dose/intensity and frequency of pain relief needed (analgesic/rescue medication use) · Adolescents/teenagers undergoing orthodontic treatment
1 finding from 1 review

Intervention not reported

Responder rate (≥ 50% reduction in overall seizure frequency) · people with epilepsy and intellectual disability

The intervention may leads to higher responder rate (≥ 50% reduction in overall seizure frequency) (low certainty).

1 finding from 1 review

Intervention not reported

Responder rate (≥ 50% reduction in rate of drop seizures) · people with epilepsy and intellectual disability

The intervention showed no clear difference in responder rate (≥ 50% reduction in rate of drop seizures) (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events 4 studies reported the frequency of self reported adverse events in the AED and placebo groups The results show a trend in favour of the placebo groups · people with epilepsy and intellectual disability

The intervention showed no clear difference in adverse events 4 studies reported the frequency of self reported… (moderate certainty).

1 finding from 1 review

Intervention not reported

Although a higher percentage of people in the ATL and aCCT groups fell within Class I (seizure free) and Class II (> 50% reduction in seizures), no significant differences in seizure frequency were noted between the groups at 2 years after surgery... · people with temporal lobe epilepsy and intellectual disabilities
1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Video 'fairytale' vs. no audiovisual aid (Passive) ICC = 0 (perfect vs. poor‐moderate compliance) · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Video 'fairytale' vs. no audiovisual… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ 2 parents vs. 1 parent Poor compliance: ICC > 6 · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ 2 parents vs. 1 parent Poor… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Parental presence vs. midazolam Poor compliance: ICC > 6 · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Parental presence vs. midazolam Poor… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Low sensory stimulation vs. control (Passive) ICC = 0 · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Low sensory stimulation vs. control… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Mask introduction/exposure (Mask) ICC (number of children compliant) · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Mask introduction/exposure (Mask)… (very low certainty).

1 finding from 1 review

Intervention not reported

Anxiety during induction ‐ hypnosis vs. midazolam (Interactive) mYPAS < 24 · children

It is very uncertain whether the intervention changes anxiety during induction ‐ hypnosis vs. midazolam (Interactive)… (very low certainty).

1 finding from 1 review