What do systematic reviews say?

Perioperative chemotherapy vs primary surgery

• Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach,… 2013 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 1606 participants
  Moderate

Perioperative chemotherapy vs primary surgery

Perioperative chemotherapy showed no clear difference in disease‐free survival (landmark time 6 months) compared with primary surgery (high certainty).

• Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach,… 2013 · Cochrane Headline outcomes only
  HR 0.84 [0.69, 1.01]
  7 studies · 931 participants
  High

Perioperative chemotherapy vs primary surgery

Perioperative chemotherapy leads to lower overall survival by type of data ‐ Individual patient data compared with primary surgery (high certainty).

• Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach,… 2013 · Cochrane Headline outcomes only
  HR 0.8 [0.66, 0.97]
  8 studies · 1049 participants
  High

Perioperative chemotherapy vs primary surgery

Perioperative chemotherapy probably leads to lower overall survival by type of data ‐ Aggregated data compared with primary surgery (moderate certainty).

• Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach,… 2013 · Cochrane Headline outcomes only
  HR 0.81 [0.72, 0.92]
  6 studies · 1373 participants
  Moderate

Perioperative chemotherapy vs primary surgery

Perioperative chemotherapy showed no clear difference in overall survival by tumor site ‐ Esophagus compared with primary surgery (high certainty).

• Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach,… 2013 · Cochrane Headline outcomes only
  HR 0.87 [0.73, 1.05]
  5 studies · 473 participants
  High

Perioperative chemotherapy vs primary surgery

Perioperative chemotherapy leads to lower overall survival by tumor site ‐ GE junction compared with primary surgery (high certainty).

• Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach,… 2013 · Cochrane Headline outcomes only
  HR 0.69 [0.54, 0.87]
  6 studies · 470 participants
  High

Perioperative chemotherapy vs primary surgery

Perioperative chemotherapy showed no clear difference in overall survival by tumor site ‐ Stomach compared with primary surgery (high certainty).

• Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach,… 2013 · Cochrane Headline outcomes only
  HR 0.94 [0.82, 1.06]
  7 studies · 828 participants
  High

Perioperative chemotherapy vs primary surgery

Perioperative chemotherapy leads to lower overall survival by chemo‐/radiotherapy ‐ Chemotherapy only compared with primary surgery (high certainty).

• Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach,… 2013 · Cochrane Headline outcomes only
  HR 0.83 [0.75, 0.91]
  10 studies · 2033 participants
  High

Perioperative chemotherapy vs primary surgery

Perioperative chemotherapy probably leads to lower overall survival by chemo‐/radiotherapy ‐ Chemoradiotherapy compared with primary surgery (moderate certainty).

• Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach,… 2013 · Cochrane Headline outcomes only
  HR 0.7 [0.5, 0.99]
  4 studies · 389 participants
  Moderate

Intervention not reported

It is very uncertain whether the intervention changes survival (very low certainty).

• Prophylactic gastrojejunostomy for unresectable periampullary carcinoma 2013 · Cochrane Headline outcomes only
  HR 1.02 [0.84, 1.25]
  2 studies · 152 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes gastric outlet obstruction Clinical symptoms of vomiting with… (very low certainty).

• Prophylactic gastrojejunostomy for unresectable periampullary carcinoma 2013 · Cochrane Headline outcomes only
  RR 0.1 [0.03, 0.37]
  2 studies · 152 participants
  Very low

Intervention not reported

• Prophylactic gastrojejunostomy for unresectable periampullary carcinoma 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 87 participants
  Very low

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 73 participants
  Moderate

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 59 participants
  Moderate

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 59 participants
  Moderate

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 82 participants
  Low

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 89 participants
  Moderate

Roxithromycin vs placebo

• Systemic antibiotics for chronic rhinosinusitis without nasal polyps in adults 2011 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 64 participants
  Low

Roxithromycin vs placebo

• Systemic antibiotics for chronic rhinosinusitis without nasal polyps in adults 2011 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 64 participants
  Low

Roxithromycin vs placebo

• Systemic antibiotics for chronic rhinosinusitis without nasal polyps in adults 2011 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 64 participants
  Low