Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,954 questions · 2,335 findings · 149 reviews · Oral Health

No studies found 436 · 18.7%GRADE not reported 1,370 · 58.7%Very low 254 · 10.9%Low 173 · 7.4%Moderate 80 · 3.4%High 22 · 0.9%

Fluoride toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Proportion developing new caries · Children and adolescents aged 16 years or less

Fluoride toothpaste showed no clear difference in proportion of children developing one or more new caries compared with placebo (non-fluoride) toothpaste; GRADE not reported.

1 finding from 1 review

Fluoride toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Acquiring extrinsic tooth staining (adverse effect; stannous fluoride toothpaste) · Children and adolescents aged 16 years or less

Fluoride toothpaste led to higher acquiring extrinsic tooth staining (adverse effect; stannous… compared with placebo (non-fluoride) toothpaste; GRADE not reported.

1 finding from 1 review

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
  • Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
    Follow-up: median 7 days
    No adverse events were reported. Six trials (673 participants) reported no adverse events from the use of chlorhexidine gel; one study (Rubio-Palau 2015) reported gastrointestinal discomfort (30, 18%), dizziness (10,…
    7 studies
    GRADE not reported

Neocone vs Alvogyl

Time to initial pain relief (minutes) · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to higher time to initial pain relief (minutes) compared with alvogyl; GRADE not reported.

1 finding from 1 review