Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,736 questions · 15,265 findings · 1,163 reviews · Headline outcomes only

No studies found 3,871 · 25.4%GRADE not reported 810 · 5.3%Very low 4,242 · 27.8%Low 3,879 · 25.4%Moderate 1,999 · 13.1%High 464 · 3%

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Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Periventricular leukomalacia · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes periventricular leukomalacia compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Length of hospital stay · neonates with sepsis

Pentoxifylline with antibiotics (any dose or duration) showed no clear difference in length of hospital stay (LOS) in days compared with placebo or no intervention (low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Necrotising enterocolitis · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes necrotising enterocolitis, any Bell stage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Retinopathy of prematurity · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes retinopathy of prematurity, any stage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Hormonal therapy vs placebo or no intervention

Effect on later sexual function · symptomatic or early postmenopausal women1.
4 findings from 1 review
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Hormonal therapy vs placebo or no intervention

Effect on later sexual function · Postmenopausal women
5 findings from 1 review
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