Spontaneous pain in the TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral gabapentin (anticonvulsant) led to lower spontaneous pain in the TMJ (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Pain at rest (not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral diclofenac sodium (NSAID) showed no clear difference in pain at rest (not improved) compared with placebo; GRADE not reported.
1 finding from 1 review
Jaw pain (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral cyclobenzaprine (muscle relaxant) showed no clear difference in jaw pain (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Reduction in pain intensity · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral propranolol (beta-blocker) led to lower reduction in pain intensity (percentage of patients responding) compared with placebo; GRADE not reported.
2 findings from 1 review
Tchivileva et al 2010: a significantly greater percentage of patients (67.5% versus 32.5%) experienced reduction in pain intensity rating during the propranolol treatment period than the placebo treatment period (P =…
1 study · 40 participants
GRADE not reported
Tchivileva et al 2010: Reduction in pain intensity rating (primary outcome) comparing propranolol treatment to placebo treatment did not reach statistical significance (P = 0.104); pairwise differences between…
1 study · 40 participants
GRADE not reported
Limitation of movement · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)
The review found no eligible studies for this question.
1 finding from 1 review
Jaw pain (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral clonazepam (benzodiazepine) showed no clear difference in jaw pain (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Reduction in pain duration (percentage of day) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral propranolol (beta-blocker) showed no clear difference in reduction in pain duration (percentage of day) compared with placebo; GRADE not reported.
1 finding from 1 review
Adverse events ‐ treatment emergent · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review
Tchivileva et al 2010: at least one treatment-emergent adverse event was reported by five participants (12.5%) during the propranolol period (nausea, diarrhoea, insomnia, dizziness, fatigue) and four participants (10%)…
1 study · 40 participants
GRADE not reported
Participants' assessment of improvement of pain in left TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral clonazepam (benzodiazepine) showed no clear difference in participants' assessment of improvement of pain in left TMJ (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Pain on palpation of left masseter muscle (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral clonazepam (benzodiazepine) showed no clear difference in pain on palpation of left masseter muscle (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Number of participants with severe dysfunction (pain of TMD not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral piroxicam (NSAID) showed no clear difference in number of participants with severe dysfunction (pain of TMD not… compared with placebo; GRADE not reported.
1 finding from 1 review
Pain on daily activity (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Topical capsaicin (0.025% cream) showed no clear difference in pain on daily activity (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review
Herman et al 2002 (cyclobenzaprine) reported adverse effects. Per the review's Adverse effects of interventions section: 'All but one study (Lobo et al 2004) reported adverse effects. Most of the reported adverse…
1 study · 41 participants
GRADE not reported
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral celecoxib (COX-2 inhibitor) showed no clear difference in pain intensity (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Maximum pain while on medication (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Topical capsaicin (0.025% cream) showed no clear difference in maximum pain while on medication (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral naproxen (NSAID) led to lower pain intensity (VAS) compared with placebo; GRADE not reported.
1 finding from 1 review
Tenderness on palpation of three or more masticatory muscles · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
Oral diclofenac sodium (NSAID) showed no clear difference in tenderness on palpation of three or more masticatory muscles compared with placebo; GRADE not reported.
1 finding from 1 review
Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review
Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review
Ta and Dionne 2004 (naproxen) reported adverse effects. Per the review: 'All but one study (Lobo et al 2004) reported adverse effects. Most of the reported adverse effects were mild and similar to the adverse effects…
1 study · 68 participants
GRADE not reported
Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review
Ta and Dionne 2004 (celecoxib) reported adverse effects. Per the review: 'All but one study (Lobo et al 2004) reported adverse effects. Most of the reported adverse effects were mild and similar to the adverse effects…
1 study · 68 participants
GRADE not reported