Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 194 findings · 24 reviews · Headline outcomes only

No studies found 45 · 23.2%GRADE not reported 5 · 2.6%Very low 48 · 24.7%Low 35 · 18%Moderate 42 · 21.6%High 19 · 9.8%

Summary of findings table ‐ Methylprednisolone vs dexamethasone

All‐cause mortality up to 30 days · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19

It is very uncertain whether summary of findings table ‐ Methylprednisolone changes all‐cause mortality up to 30 days compared with dexamethasone (very low certainty).

1 finding from 1 review

Treatment route: intravenous corticosteroid vs oral corticosteroid

Mortality after discharge (1‐3 months) · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in mortality after discharge (1‐3 months) compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Treatment route: intravenous corticosteroid vs oral corticosteroid

Treatment failure Need for additional treatment · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in treatment failure Need to intensify therapy compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Treatment route: intravenous corticosteroid vs oral corticosteroid

Relapse Hospital readmission for COPD · exacerbations of COPD

Treatment route: intravenous corticosteroid showed no clear difference in relapse Hospital readmission for COPD compared with oral corticosteroid (moderate certainty).

1 finding from 1 review