What do systematic reviews say?

Summary of findings. Home vs hospital‐clinic removal of casts

Summary of findings. Home may leads to lower participant satisfaction: Parents would not choose the same… compared with hospital‐clinic removal of casts (low certainty).

• Interventions for treating wrist fractures in children 2018 · Cochrane Headline outcomes only
  RR 0.16 [0.06, 0.43]
  1 study · 80 participants
  Low

Summary of findings: IMRT vs 3DCRT

Summary of findings: IMRT showed no clear difference in mean GI symptom scores (EORTC‐QLQPR25 scale; lower scores better) compared with 3DCRT (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 181 participants
  Low

Summary of findings: IMRT vs 3DCRT

Summary of findings: IMRT may leads to lower acute and late GI toxicity Grade 2+ compared with 3DCRT (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 0.48 [0.26, 0.88]
  4 studies · 444 participants
  Low

Summary of findings: IMRT vs 3DCRT

Summary of findings: IMRT may leads to lower diarrhoea (grade 2+) compared with 3DCRT (low certainty).

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  RR 0.38 [0.22, 0.68]
  1 study · 72 participants
  Low

Summary of findings: IMRT vs 3DCRT

• Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  GRADE not reported

Summary of findings: ring vs clip

Summary of findings: ring showed no clear difference in major morbidity: total compared with clip (low certainty).

• Techniques for the interruption of tubal patency for female sterilisation 2016 · Cochrane Headline outcomes only
  OR 0.14 [0, 7.05]
  1 study · 545 participants
  Low

Summary of findings: ring vs clip

Summary of findings: ring leads to higher minor morbidity: total compared with clip (high certainty).

• Techniques for the interruption of tubal patency for female sterilisation 2016 · Cochrane Headline outcomes only
  OR 2.15 [1.22, 3.78]
  2 studies · 842 participants
  High

Summary of findings: ring vs clip

Summary of findings: ring leads to higher minor morbidity: details ‐ procedure‐related injuries compared with clip (high certainty).

• Techniques for the interruption of tubal patency for female sterilisation 2016 · Cochrane Headline outcomes only
  OR 1.95 [1.36, 2.78]
  3 studies · 3575 participants
  High

Summary of findings: ring vs clip

Summary of findings: ring leads to higher technical failures compared with clip (high certainty).

• Techniques for the interruption of tubal patency for female sterilisation 2016 · Cochrane Headline outcomes only
  OR 3.93 [2.43, 6.35]
  3 studies · 3476 participants
  High

Summary of findings: ring vs clip

Summary of findings: ring showed no clear difference in failure rate: details (12 to 24 months) compared with clip (high certainty).

• Techniques for the interruption of tubal patency for female sterilisation 2016 · Cochrane Headline outcomes only
  OR 0.72 [0.33, 1.57]
  4 studies · 3822 participants
  High

Summary of findings: ring vs clip

Summary of findings: ring showed no clear difference in complaints: Postoperative pain (24 hours) compared with clip (high certainty).

• Techniques for the interruption of tubal patency for female sterilisation 2016 · Cochrane Headline outcomes only
  OR 1.14 [0.88, 1.48]
  3 studies · 922 participants
  High

Summary of findings: EBRT vs no EBRT

Summary of findings: EBRT showed no clear difference in death from all causes compared with no EBRT (moderate certainty).

• Adjuvant radiotherapy for stage I endometrial cancer 2012 · Cochrane Headline outcomes only
  HR 0.99 [0.82, 1.2]
  2628 participants
  Moderate

Summary of findings: EBRT vs no EBRT

Summary of findings: EBRT showed no clear difference in endometrial carcinoma‐related death compared with no EBRT (moderate certainty).

• Adjuvant radiotherapy for stage I endometrial cancer 2012 · Cochrane Headline outcomes only
  HR 0.96 [0.72, 1.28]
  2965 participants
  Moderate

Summary of findings: EBRT vs no EBRT

Summary of findings: EBRT leads to lower locoregional recurrence compared with no EBRT (high certainty).

• Adjuvant radiotherapy for stage I endometrial cancer 2012 · Cochrane Headline outcomes only
  HR 0.36 [0.25, 0.52]
  2965 participants
  High

Summary of findings: EBRT vs no EBRT

Summary of findings: EBRT leads to higher severe acute toxicity compared with no EBRT (high certainty).

• Adjuvant radiotherapy for stage I endometrial cancer 2012 · Cochrane Headline outcomes only
  RR 4.68 [1.35, 16.16]
  1328 participants
  High

Summary of findings: EBRT vs no EBRT

Summary of findings: EBRT leads to higher severe late toxicity compared with no EBRT (high certainty).

• Adjuvant radiotherapy for stage I endometrial cancer 2012 · Cochrane Headline outcomes only
  RR 2.58 [1.61, 4.11]
  3501 participants
  High

Zinc vs placebo

Summary of findings – zinc probably leads to higher BMD Z score (total hip/femoral neck) compared with placebo (moderate certainty).

• Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
  MD 0.15 [0.11, 0.19]
  1 study · 37 participants
  Moderate

Zinc vs placebo

Summary of findings – zinc probably leads to higher BMD Z score (lumbar spine) compared with placebo (moderate certainty).

• Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
  MD 0.15 [0.1, 0.2]
  1 study · 37 participants
  Moderate

Zinc vs placebo

The review found no eligible studies for this question.

• Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Zinc vs placebo

The review found no eligible studies for this question.

• Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found