Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

309 questions · 325 findings · 45 reviews · Acute Respiratory Infections

No studies found 38 · 11.7%GRADE not reported 31 · 9.5%Very low 54 · 16.6%Low 78 · 24%Moderate 106 · 32.6%High 18 · 5.5%

Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care

Recurrence of ARTI · children aged up to 16 years with ARTIs

Homeopathic medicinal products (non‐individualised treatment) showed no clear difference in recurrence of ARTI compared with placebo or usual care (low certainty).

1 finding from 1 review

Probiotics vs placebo or no treatment

Number of participants who were diagnosed with acute URTIs: at least 1 event · children, adults, and the elderly

Intention‐to‐treat analysis: probiotics may leads to lower number of participants who were diagnosed with acute URTIs: at least… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Probiotics vs placebo or no treatment

Number of participants who were diagnosed with acute URTIs: at least 3 events · children, adults, and the elderly

Intention‐to‐treat analysis: probiotics probably leads to lower number of participants who were diagnosed with acute URTIs: at least… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Probiotics vs placebo or no treatment

Incidence of acute URTIs during the study period (the number of acute URTIs over a period of time) · children, adults, and the elderly

Intention‐to‐treat analysis: probiotics may leads to lower incidence rate of acute URTIs compared with placebo or no treatment (low certainty).

1 finding from 1 review

Probiotics vs placebo or no treatment

Number of participants who were absent from childcare centre, school, or work due to acute URTIs · children, adults, and the elderly

It is very uncertain whether intention‐to‐treat analysis: probiotics changes number of participants who were absent from childcare centre,… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Point‐of‐care biomarkers (procalcitonin) for infection vs usual care

Clinical recovery · people with acute respiratory infections

The review found no eligible studies for this question.

2 findings from 1 review

Point‐of‐care biomarkers (C‐reactive protein) for infection vs usual care

Clinical recovery · people with acute respiratory infections
2 findings from 1 review

Vitamin C vs placebo

Incidence of pneumonia Defined as patient admitted to hospital with a diagnosis of pneumonia Dose: 2 g per day · school‐aged children (6 to 15 years) and marine corps recruits (mean age 18.5 years)

It is very uncertain whether vitamin C changes incidence of pneumonia Defined as patient admitted to hospital with… compared with placebo (very low certainty).

1 finding from 1 review

Vitamin C vs placebo

Adverse effects (urticaria) Defined as participants reporting urticaria (hives) Dose: 2 g per day · school‐aged children (6 to 15 years) and marine corps recruits (mean age 18.5 years)

It is very uncertain whether vitamin C changes adverse effects (urticaria) Defined as participants reporting… compared with placebo (very low certainty).

1 finding from 1 review