Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

290 questions · 295 findings · 24 reviews · Haematology

No studies found 73 · 24.7%GRADE not reported 23 · 7.8%Very low 55 · 18.6%Low 96 · 32.5%Moderate 37 · 12.5%High 11 · 3.7%

Azithromycin vs placebo or usual care

Serious adverse events during the study period · people with moderate to severe disease (WHO scale 4–9); all studies contributing results to the summary of findings table included people…

Azithromycin showed no clear difference in serious adverse events during the study period compared with placebo or standard of care alone (moderate certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

Adverse events during treatment period · people with moderate to severe disease (WHO scale 4–9); all studies contributing results to the summary of findings table included people…

Azithromycin showed no clear difference in any adverse events during the study period compared with placebo or standard of care alone (low certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

Arrhythmias · people with moderate to severe disease (WHO scale 4–9); all studies contributing results to the summary of findings table included people…

Azithromycin showed no clear difference in cardiac arrhythmias during the study period compared with placebo or standard of care alone (moderate certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

All‐cause mortality at day 28 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

Azithromycin showed no clear difference in all‐cause mortality at day 28 compared with placebo or standard of care alone (low certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

Admission to hospital or death within 28 days · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

Azithromycin showed no clear difference in admission to hospital or death within 28 days compared with placebo or standard of care alone (low certainty).

1 finding from 1 review