Occurrence of HAEC · children with Hirschsprung's disease (HD)
It is very uncertain whether probiotics changes occurrence of HAEC compared with placebo (very low certainty).
1 finding from 1 review
Serious adverse events · children with Hirschsprung's disease (HD)
1 finding from 1 review
Severity of HAEC Â · children with Hirschsprung's disease (HD)
Probiotics showed no clear difference in severity of HAEC Â compared with placebo (low certainty).
1 finding from 1 review
Overall mortality · children with Hirschsprung's disease (HD)
1 finding from 1 review
Withdrawals due to adverse events · children with Hirschsprung's disease (HD)
1 finding from 1 review
Recurrent episodes of HAEC · children with Hirschsprung's disease (HD)
Probiotics showed no clear difference in recurrent episodes of HAEC compared with placebo (low certainty).
1 finding from 1 review
Failure to induce clinical remission at end of study · people with active UC
Antibiotics showed no clear difference in failure to induce clinical remission at end of study compared with placebo (high certainty).
1 finding from 1 review
Failure to induce clinical response at end of study · people with active UC
Antibiotics showed no clear difference in failure to induce clinical response at end of study compared with placebo (low certainty).
1 finding from 1 review
Serious adverse events · people with active UC
Antibiotics showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with active UC
Antibiotics showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).
1 finding from 1 review
Failure to induce clinical remission at end of study · people with active UC
It is very uncertain whether antibiotics plus probiotics changes failure to induce clinical remission at end of study compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Failure to induce clinical response at end of study · people with active UC
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serious adverse events · people with active UC
It is very uncertain whether antibiotics plus probiotics changes serious adverse events compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with active UC
It is very uncertain whether antibiotics plus probiotics changes withdrawals due to adverse events compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Failure to maintain clinical remission at end of study · people with Crohn's disease who responded to CZP remission‐induction treatment
Certolizumab pegol probably leads to lower failure to maintain clinical remission at week 26(1 RCT, 428… compared with placebo (moderate certainty).
1 finding from 1 review
RR 0.73 [0.63, 0.85]
Studies not reported
Moderate
Failure to maintain clinical response · people with Crohn's disease who responded to CZP remission‐induction treatment
Certolizumab pegol probably leads to lower failure to maintain clinical response at week 26(1 RCT, 428… compared with placebo (moderate certainty).
1 finding from 1 review
RR 0.58 [0.48, 0.71]
Studies not reported
Moderate
Any severe adverse event during maintenance treatment · people with Crohn's disease who responded to CZP remission‐induction treatment
Certolizumab pegol showed no clear difference in serious adverse events during remission maintenance treatment(1 RCT,… compared with placebo (low certainty).
1 finding from 1 review
RR 0.84 [0.4, 1.78]
Studies not reported
Low
Frequency of defecation (mean number of bowel movements per week) · children with chronic constipation without a physical explanation
1 finding from 1 review
Frequency of defecation (mean number of bowel movements per week) · children with chronic constipation without a physical explanation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Global improvement or treatment success, as defined by primary study · children with chronic constipation without a physical explanation
Synbiotics may leads to higher global improvement or treatment success, as defined by primary study compared with placebo (low certainty).
1 finding from 1 review