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Evidence found and GRADE certainty

537 questions · 560 findings · 45 reviews · Common Mental Disorders

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No studies found 105 · 18.8%GRADE not reported 8 · 1.4%Very low 170 · 30.4%Low 153 · 27.3%Moderate 94 · 16.8%High 30 · 5.4%

Cell signal transducers vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with trichotillomania

Cell signal transducers showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).

1 finding from 1 review

Glutamate modulators vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with trichotillomania

Glutamate modulators probably leads to higher treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (moderate certainty).

1 finding from 1 review

Glutamate modulators vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · children and adolescents with trichotillomania

Glutamate modulators showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).

1 finding from 1 review

Glutamate modulators vs placebo

Dropouts due to adverse events · children and adolescents with trichotillomania

Glutamate modulators showed no clear difference in tolerability of treatment ‐ dropouts due to adverse eventscDropout… compared with placebo (low certainty).

1 finding from 1 review

Opioid antagonists vs placebo

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CGI‐I) (no. of responders) & NIMH Trichotillomania Severity Scale (NIMH‐TSS) (no. of responders as > 50% reduction) · adults with trichotillomania

It is very uncertain whether opioid antagonists changes treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (very low certainty).

1 finding from 1 review

Antioxidants vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review

TCAs with predominantly SRI actions vs placebo

Clinical Global Impressions scale change item (CGI‐I): no. of responders (long term) Post‐treatment: 1‐4 months · adults with trichotillomania

It is very uncertain whether TCAs with predominantly SRI actions changes treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (very low certainty).

1 finding from 1 review

TCAs with predominantly SRI actions vs placebo

Dropouts due to adverse events · adults with trichotillomania

It is very uncertain whether TCAs with predominantly SRI actions changes tolerability of treatment ‐ dropouts due to adverse eventsdDropout… compared with placebo (very low certainty).

1 finding from 1 review