Findings

What do systematic reviews say?

489 questions · 532 findings · 33 reviews · Headline outcomes only

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No studies found 55 · 10.3%GRADE not reported 28 · 5.3%Very low 119 · 22.4%Low 167 · 31.4%Moderate 129 · 24.2%High 34 · 6.4%

Summary of findings ‐ monotherapy: cavosonstat vs placebo

Time to first pulmonary exacerbation · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ monotherapy: cavosonstat vs placebo

Survival · adults and children with cystic fibrosis

1 finding from 1 review

Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 26 participants
Very low

Summary of findings ‐ monotherapy: cavosonstat vs placebo

Quality of life: total score · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Interpersonal Psychotherapy adapted for BPD (IPT‐BPD) vs clinical management (CM)

BPD total severityBPDSI‐IV1‐total score · patients with borderline personality disorder

1 finding from 1 review

Psychological therapies for people with borderline personality disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Interpersonal Psychotherapy adapted for BPD (IPT‐BPD) vs clinical management (CM)

AngerBPDSI‐IV1‐anger · patients with borderline personality disorder

1 finding from 1 review

Psychological therapies for people with borderline personality disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Interpersonal Psychotherapy adapted for BPD (IPT‐BPD) vs clinical management (CM)

Affective instabilityBPDSI‐IV1‐affective instability · patients with borderline personality disorder

1 finding from 1 review

Psychological therapies for people with borderline personality disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Interpersonal Psychotherapy adapted for BPD (IPT‐BPD) vs clinical management (CM)

Chronic feelings of emptinessBPDSI‐IV1‐emptiness · patients with borderline personality disorder

1 finding from 1 review

Psychological therapies for people with borderline personality disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Interpersonal Psychotherapy adapted for BPD (IPT‐BPD) vs clinical management (CM)

Impulsivity · patients with borderline personality disorder

1 finding from 1 review

Psychological therapies for people with borderline personality disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Interpersonal Psychotherapy adapted for BPD (IPT‐BPD) vs clinical management (CM)

ParasuicidalityBPDSI‐IV1‐parasuicidal behaviour · patients with borderline personality disorder

1 finding from 1 review

Psychological therapies for people with borderline personality disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Interpersonal Psychotherapy adapted for BPD (IPT‐BPD) vs clinical management (CM)

Interpersonal problemsBPDSI‐IV1‐interpersonal relationships · patients with borderline personality disorder

1 finding from 1 review

Psychological therapies for people with borderline personality disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Interpersonal Psychotherapy adapted for BPD (IPT‐BPD) vs clinical management (CM)

Avoidance of abandonment BPDSI‐IV1‐abandonment · patients with borderline personality disorder

1 finding from 1 review

Psychological therapies for people with borderline personality disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Interpersonal Psychotherapy adapted for BPD (IPT‐BPD) vs clinical management (CM)

Identity disturbance BPDSI‐IV1‐identity disturbance · patients with borderline personality disorder

1 finding from 1 review

Psychological therapies for people with borderline personality disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Interpersonal Psychotherapy adapted for BPD (IPT‐BPD) vs clinical management (CM)

Dissociation/paranoid ideation BPDSI‐IV1‐paranoid ideation · patients with borderline personality disorder

1 finding from 1 review

Psychological therapies for people with borderline personality disorder 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Intervention not reported

Any neurological sequelae other than hearing loss defined as health consequences of the infection that involve the central nervous system during the · children with acute bacterial meningitis

The intervention showed no clear difference in any neurological sequelae other than hearing loss defined as health… (low certainty).

1 finding from 1 review

Non‐corticosteroid adjuvant therapies for acute bacterial meningitis 2021 · Cochrane Headline outcomes only
RR 1.56 [0.98, 2.5]
3 studies · 1274 participants
Low

Intervention not reported

Short‐term neurological sequelae other than hearing loss defined as sequelae present up to 6 weeks after hospital discharge · children with acute bacterial meningitis

The intervention may leads to higher short‐term neurological sequelae other than hearing loss defined as… (low certainty).

1 finding from 1 review

Non‐corticosteroid adjuvant therapies for acute bacterial meningitis 2021 · Cochrane Headline outcomes only
RR 1.99 [1.4, 2.81]
2 studies · 1096 participants
Low

Intervention not reported

Long‐term neurological sequelae other than hearing loss defined as sequelae present between 6 weeks after hospital discharge and the last time point reported in the study · children with acute bacterial meningitis

The intervention may leads to higher long‐term neurological sequelae other than hearing loss defined as… (low certainty).

1 finding from 1 review

Non‐corticosteroid adjuvant therapies for acute bacterial meningitis 2021 · Cochrane Headline outcomes only
RR 2.32 [1.34, 4.04]
2 studies · 901 participants
Low

CBT vs ALL OTHER PSYCHOLOGICAL THERAPIES

Relapse · patients with schizophrenia

CBT showed no clear difference in global state: relapse compared with ALL OTHER PSYCHOLOGICAL THERAPIES (low certainty).

1 finding from 1 review

Cognitive behavioural therapy plus standard care versus standard care plus other psychosocial treatments for people… 2018 · Cochrane Headline outcomes only
RR 1.05 [0.85, 1.29]
5 studies · 375 participants
Low

CBT vs ALL OTHER PSYCHOLOGICAL THERAPIES

Patient readmissions · patients with schizophrenia

CBT showed no clear difference in global state: rehospitalisation* compared with ALL OTHER PSYCHOLOGICAL THERAPIES (low certainty).

1 finding from 1 review

Cognitive behavioural therapy plus standard care versus standard care plus other psychosocial treatments for people… 2018 · Cochrane Headline outcomes only
RR 0.96 [0.82, 1.14]
8 studies · 943 participants
Low

CBT vs ALL OTHER PSYCHOLOGICAL THERAPIES

Mental state: General ‐ clinically important change (no improvement) · patients with schizophrenia

CBT showed no clear difference in mental state: General ‐ clinically important change (no improvement) compared with ALL OTHER PSYCHOLOGICAL THERAPIES (low certainty).

1 finding from 1 review

Cognitive behavioural therapy plus standard care versus standard care plus other psychosocial treatments for people… 2018 · Cochrane Headline outcomes only
RR 0.82 [0.67, 1.01]
4 studies · 249 participants
Low

CBT vs ALL OTHER PSYCHOLOGICAL THERAPIES

Adverse effect/event: death ‐ any cause · patients with schizophrenia

CBT showed no clear difference in adverse effect/event: death ‐ any cause compared with ALL OTHER PSYCHOLOGICAL THERAPIES (low certainty).

1 finding from 1 review

Cognitive behavioural therapy plus standard care versus standard care plus other psychosocial treatments for people… 2018 · Cochrane Headline outcomes only
RR 1.57 [0.62, 3.98]
6 studies · 627 participants
Low