Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

433 questions · 520 findings · 26 reviews

No studies found 158 · 30.4%GRADE not reported 136 · 26.2%Very low 123 · 23.7%Low 58 · 11.2%Moderate 37 · 7.1%High 8 · 1.5%

Injectional collagenase vs placebo

Treatment discontinuation · men with Peyronie's disease (diagnosis of disease: at least 12 months, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

2 findings from 1 review

Injectional verapamil vs saline (short‐term)

Patient‐reported ability to have intercourse · men with Peyronie's disease (palpable plaque or pain)

It is very uncertain whether injectional verapamil changes patient‐reported ability to have intercourse compared with saline (short‐term) (very low certainty).

1 finding from 1 review

Potassium paraaminobenzoate vs placebo

Treatment‐related adverse effects · men with acute (maximum of 12 months) Peyronie's disease with no prior treatment and no evidence of calcified plaques (pain during…

It is very uncertain whether potassium paraaminobenzoate changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Extracorporeal shockwave therapy vs sham

Patient‐reported ability to have intercourse · men with Peyronie's disease (palpable plaque or pain)

It is very uncertain whether extracorporeal shock wave treatment (ESWT) changes patient‐reported ability to have intercourse compared with sham (very low certainty).

1 finding from 1 review