Rufinamide probably leads to higher adverse effects: fatigue compared with placebo (moderate certainty).
Rufinamide probably leads to higher adverse effects: headache compared with placebo (moderate certainty).
Rufinamide probably leads to higher adverse effects: somnolence compared with placebo (moderate certainty).
Rufinamide probably leads to higher adverse effects: nausea compared with placebo (moderate certainty).
Rufinamide may leads to higher adverse effects: vomiting compared with placebo (low certainty).
Topiramate leads to higher 50% or greater reduction in seizure frequency (ITT analysis) compared with placebo (high certainty).
Topiramate probably leads to higher seizure freedom compared with placebo (moderate certainty).
Topiramate leads to higher treatment withdrawal compared with placebo (high certainty).
Topiramate may leads to higher adverse effects ‐ weight loss/decrease compared with placebo (low certainty).
Topiramate probably leads to higher adverse effects ‐ paraesthesia compared with placebo (moderate certainty).
Topiramate leads to higher adverse effects ‐ 'thinking abnormally' compared with placebo (high certainty).
Topiramate probably leads to higher adverse effects ‐ difficulty with concentration/concentration… compared with placebo (moderate certainty).
Tiagabine leads to higher 50% or greater reduction in seizure frequency (Intention‐to‐treat… compared with placebo control (high certainty).
Tiagabine probably leads to higher treatment withdrawal compared with placebo control (moderate certainty).
Tiagabine probably leads to higher dizziness compared with placebo control (moderate certainty).
Tiagabine showed no clear difference in fatigue compared with placebo control (moderate certainty).
Tiagabine showed no clear difference in nausea compared with placebo control (low certainty).
Tiagabine showed no clear difference in somnolence compared with placebo control (moderate certainty).
Tiagabine showed no clear difference in tremor compared with placebo control (low certainty).
Carbamazepine showed no clear difference in time to treatment failure (any reason related to treatment)All… compared with phenytoin (time to treatment failure) (moderate certainty).