Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

579 questions · 601 findings · 56 reviews

No studies found 143 · 23.8%GRADE not reported 69 · 11.5%Very low 101 · 16.8%Low 142 · 23.6%Moderate 116 · 19.3%High 30 · 5%

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal clinical malaria or other infection in pregnancy · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… led to lower maternal clinical malaria or other infection in pregnancy compared with daily regimen (with same vitamins and minerals)‐maternal outcomes; GRADE not reported.

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Birthweight (g) · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in birthweight (g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Gestational age (preterm birth < 37 weeks) · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in premature birth (less than 37 weeks of gestation) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Neonatal mortality · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes neonatal death (within 28 days after delivery) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (very low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL) · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes maternal anaemia at term (Hb less than 110 g/L at 37 weeks'… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and at least 1 additional laboratory indicators at 37 weeks' gestation or more) · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal death · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… led to lower maternal death (death while pregnant or within 42 days of… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes; GRADE not reported.

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 6 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 6 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 12 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 12 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 18 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 18 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Intermittent rectal diclofenac vs placebo followed after 8 hours by oral ibuprofen, acetaminophen or placebo

Recurrent seizure at 24 months · children with febrile seizures

Intermittent rectal diclofenac showed no clear difference in recurrent seizure at 24 months compared with placebo, followed by oral ibuprofen, paracetamol, or placebo after 8… (high certainty).

1 finding from 1 review

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Doppler vs routine Pinard (outcomes

Apgar score less than 7 at 5 minutes · women in established labour and their babies.

It is very uncertain whether intermittent ausculation of fetal heart rate in labour for fetal… changes apgar < 7 at 5 minutes compared with routine Pinard (outcomes (very low certainty).

1 finding from 1 review

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Doppler vs routine Pinard (outcomes

Neonatal seizures · women in established labour and their babies.

It is very uncertain whether intermittent ausculation of fetal heart rate in labour for fetal… changes seizures in the neonatal period compared with routine Pinard (outcomes (very low certainty).

1 finding from 1 review

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Doppler vs routine Pinard (outcomes

Perinatal mortality · women in established labour and their babies.

It is very uncertain whether intermittent ausculation of fetal heart rate in labour for fetal… changes perinatal mortality compared with routine Pinard (outcomes (very low certainty).

1 finding from 1 review