Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

336 questions · 357 findings · 36 reviews

No studies found 65 · 18.2%GRADE not reported 16 · 4.5%Very low 87 · 24.4%Low 114 · 31.9%Moderate 60 · 16.8%High 15 · 4.2%

Estimates of effects, ranking, and certainty of evidence for different treatment options vs placebo

Interferon + SSA (2 RCTs; 171 participants)

It is very uncertain whether estimates of effects, ranking, and certainty of evidence for… changes interferon + SSA (2 RCTs; 468 participants) compared with placebo (very low certainty).

4 findings from 1 review
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Estimates of effects, ranking, and certainty of evidence for different treatment options vs placebo

Interferon (1 RCT; 66 participants)

It is very uncertain whether estimates of effects, ranking, and certainty of evidence for… changes interferon (1 RCT; 66 participants) compared with placebo (very low certainty).

4 findings from 1 review
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Rituximab vs other disease‐modifying treatments

Interferon beta or glatiramer acetate · relapsing multiple sclerosis

Rituximab as 'switching' probably leads to higher interferon beta or glatiramer acetate compared with other disease‐modifying treatments (moderate certainty).

2 findings from 1 review

Intervention vs no intervention or control intervention (control)

Serious adverse events (number) ‐ pegylated interferon‐alpha plus ribavirin versus pegylated interferon‐alpha · people with acute hepatitis C infection

It is very uncertain whether intervention changes serious adverse events (proportion) ‐ pegylated interferon‐alpha… compared with no intervention or control intervention (control) (very low certainty).

2 findings from 1 review

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ interferon‐alpha versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ interferon‐alpha versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ interferon‐beta versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ interferon‐beta versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Chronic HCV infection†‐ pegylated interferon‐alpha plus ribavirin versus pegylated interferon‐alpha · people with acute hepatitis C infection

It is very uncertain whether intervention changes chronic HCV infection†‐ pegylated interferon‐alpha plus ribavirin… compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Adverse events (proportion) ‐ interferon‐alpha versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes adverse events (proportion) ‐ interferon‐alpha versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Adverse events (number) ‐ interferon‐beta versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes adverse events (proportion) ‐ interferon‐beta versus no intervention compared with no intervention or control intervention (control) (very low certainty).

2 findings from 1 review