Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

257 questions · 270 findings · 42 reviews · Headline outcomes only

No studies found 75 · 27.8%GRADE not reported 7 · 2.6%Very low 95 · 35.2%Low 50 · 18.5%Moderate 40 · 14.8%High 3 · 1.1%

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Metformin Diagnostic criteria: 2 studies applied the WHO 1999 criteria for 'prediabetes' (FPG > 6.1 mmol/L and < 7.0 mmol/L and/or a 2‐h glucose < 11.1 mmol/L after a 75 g OGTT; Chen 2007a; Zeng 2013) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy showed no clear difference in metformin Diagnostic criteria: 2 studies applied the WHO 1999… compared with another pharmacological glucose‐lowering monotherapy (low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Acarbose Diagnostic criteria: 1 study applied the WHO 1999 criteria for prediabetes (FPG > 6.1 mmol/L and < 7.0 mmol/L and/or a 2‐h glucose < 11.1 mmol/L after a 75 g OGTT; Chen 2007a) · people at increased risk for developing type 2 diabetes
1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Repaglinide Diagnostic criteria: 1 study applied the ADA 2010 criteria (FPG ≥ 5.6 mmol/L and < 6.9 mmol/L and 2‐h glucose ≥ 7.8 mmol/L or < 11.0 mmol/L after a 75 g OGTT; Zhang 2007) · people at increased risk for developing type 2 diabetes
1 finding from 1 review

Umbilical artery Doppler ultrasound vs no Doppler ultrasound

Any perinatal death after randomisation · pregnant women at increased risk of fetal complications

Umbilical artery Doppler ultrasound probably leads to lower any perinatal death after randomisation compared with no Doppler ultrasound (moderate certainty).

1 finding from 1 review

Computerised antenatal CTG vs traditional antenatal CTG (women at increased risk of complications)

Apgar score less than 7 at 5 minutes · Pregnant women with/without complications

It is very uncertain whether computerised antenatal CTG changes apgar less than 7 at 5 minutes compared with traditional antenatal CTG (women at increased risk of complications) (very low certainty).

1 finding from 1 review